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Bringing people and ideas together to fund, conduct, and share transformative science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. Good practices for Bayesian inference in statistical learning.

    Current Opinion in Neurobiology, August 28, 2026

    Tamás Kovács and Máté Lengyel

  2. Natural auditory behaviors invoke cognitive brain networks.

    Current Opinion in Neurobiology, August 2026

    Aditya Krishna, Grace Capshaw, and Cynthia F Moss

  3. Harnessing theoretical neuroscience to understand decision-making across aging.

    Current Opinion in Neurobiology, August 2026

    Michael B Ryan, Letizia Ye, and Anne K Churchland

  4. The Simons Collaboration on Ecological Neuroscience: Studying how the brain interacts with the world.

    Neuron, July 15, 2026

    Dora E Angelaki, Aaron Batista, Tesca Fitzgerald, Jonathan F Kominsky, Máté Lengyel, Alexander Mathis, et al.

  5. From peripersonal space to cognitive maps: An evolutionary perspective.

    Progress in Neurobiology, July 2026

    Summbla Anjum, Maria J Sosa, Andrea Serino, and Jean-Paul Noel

  6. Keeping neurons in shape with fats: an educational primer for use with "Phospholipid biogenesis maintains neuronal integrity during aging and axon regeneration".

    Genetics, May 6, 2026

    Ryan J Lee and John P Vaughen

  7. Engulfment by brain macrophages in a short-lived vertebrate.

    biorxiv:10.64898/2026.04.28.721434, April 29, 2026

    Rahul Nagvekar, Angela N Pogson, Prateek R Kalakuntla, Helena J Barr, Azalia M Martínez Jaimes, S V Perry, et al.

  8. COMPASS-mediated epigenetic regulation of transcription accelerates forgetting with age.

    researchsquare:10.21203/rs.3.rs-9395284/v1, April 27, 2026

    Titas Sengupta, Rachel Kaletsky, Katherine Morillo, Shiyi Zhou, Abigail Brown, Katherine Novak, et al.

  9. A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging.

    biorxiv:10.64898/2026.04.09.717549, April 10, 2026

    Rapheal G Williams, Bryan B Teefy, Aaron J J Lemus, Evelyn H Lee, Rajyk Bhala, Minhoo Kim, et al.

  10. Lifelong behavioral screen reveals an architecture of vertebrate aging.

    Science (New York, N.Y.), March 12, 2026

    Claire N Bedbrook, Ravi D Nath, Libby Zhang, Scott W Linderman, Anne Brunet, and Karl Deisseroth

  11. Liver exerkine reverses aging- and Alzheimer's-related memory loss via vasculature.

    Cell, March 5, 2026

    Gregor Bieri, Karishma J B Pratt, Yasuhiro Fuseya, Turan Aghayev, Juliana Sucharov, Alana M Horowitz, et al.

  12. Exposure to deceased remains of conspecifics extends the lifespan of young and aged C. elegans via distinct pathways.

    biorxiv:10.64898/2026.02.08.704602, February 10, 2026

    Erik Toraason and Coleen T Murphy

  13. Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition.

    Immunity, February 10, 2026

    Paloma Navarro Negredo, Justin You, Max Hauptschein, Adam B Schroer, Daniel J Richard, Gita C Abhiraman, et al.

  14. COUNTERING AGE-ASSOCIATED ALTERATIONS IN OLIGODENDROCYTE-DERIVED EXTRACELLULAR MATRIX REJUVENATES COGNITION.

    biorxiv:10.64898/2026.02.03.702938, February 5, 2026

    Amber R Philp, L Remesal, Karishma J B Pratt, Jason C Maynard, Shanan Sahota, Turan Aghayev, et al.

  15. Precision estimates of longitudinal brain aging capture unexpected individual differences in one year.

    Nature Communications, February 5, 2026

    Maxwell L Elliott, Jingnan Du, Jared A Nielsen, Lindsay C Hanford, Pia Kivisäkk, Steven E Arnold, et al.

  16. Aging-linked systemic lipid signature is reprogrammed by caloric restriction in rhesus monkeys.

    Molecular Systems Biology, February 2026

    Salma I Abou Elhassan, Josef P Clark, Di Kuang, Timothy W Rhoads, Ricki J Colman, Joshua J Coon, et al.

  17. Ageing promotes microglial accumulation of slow-degrading synaptic proteins.

    Nature, February 2026

    Ian H Guldner, Viktoria P Wagner, Patricia Moran-Losada, Sophia M Shi, Sophia W Golub, Johannes F Hevler, et al.

  18. Locomotion-induced gain of visual responses cannot explain visuomotor mismatch responses in layer 2/3 of primary visual cortex

    Cell Rep, March 28, 2023

    A Vasilevskaya, FC Widmer, GB Keller, and Rebecca Jordan

  19. Time-resolved correlation of distributed brain activity tracks E-I balance and accounts for diverse scale-free phenomena

    Cell Rep, March 24, 2023

    A Nanda, GW Johnson, Y Mu, Misha Ahrens, C Chang, DJ Englot, et al.

  20. Thalamus drives vocal onsets in the zebra finch courtship song

    Nature, March 23, 2023

    FW Moll, D Kranz, A Corredera Asensio, M Elmaleh, LA Ackert-Smith, and Michael A. Long

  21. Catalyzing next-generation Artificial Intelligence through NeuroAI

    Nat Commun, March 23, 2023

    Anthony Zador, S Escola, B Richards, B Ölveczky, Y Bengio, K Boahen, et al.

  22. Mechanisms of Dominant Electrophysiological Features of Four Subtypes of Layer 1 Interneurons

    J Neurosci, March 17, 2023

    JH Meng, B Schuman, B Ruby, and Xiao-Jing Wang

  23. An optical design enabling lightweight and large field-of-view head-mounted microscopes

    Nat Methods, March 17, 2023

    JR Scherrer, GF Lynch, JJ Zhang, and Michale Fee

  24. Neural learning rules for generating flexible predictions and computing the successor representation

    Elife, March 16, 2023

    C Fang, D Aronov, Larry Abbott, and EL Mackevicius

  25. Fast and sensitive GCaMP calcium indicators for imaging neural populations

    Nature, March 16, 2023

    Y Zhang, M Rózsa, Y Liang, D Bushey, Z Wei, J Zheng, et al.

  26. Fastest-ever calcium sensors broaden the potential of neuronal imaging

    Nature, March 15, 2023

    MB Ryan, Anne K. Churchland, Y Gong, and C Baker

  27. Neural circuits underlying habituation of visually evoked escape behaviors in larval zebrafish

    Elife, March 14, 2023

    H Fotowat and Florian Engert

  28. The neural architecture of theory-based reinforcement learning

    Neuron, March 10, 2023

    MS Tomov, PA Tsividis, T Pouncy, Joshua Tenenbaum, and SJ Gershman

  29. A complete biomechanical model of Hydra contractile behaviors, from neural drive to muscle to movement.

    Proc Natl Acad Sci USA, March 10, 2023

    H Wang, J Swore, S Sharma, JR Szymanski, R Yuste, TL Daniel, et al.

  30. Evolution of neural activity in circuits bridging sensory and abstract knowledge

    Elife, March 7, 2023

    F Mastrogiuseppe, N Hiratani, and Peter Latham

  31. Early impairments of visually-driven neuronal ensemble dynamics in the rTg4510 tauopathy mouse model

    Neurobiol Dis, March 3, 2023

    A Parka, C Degel, J Dreyer, U Richter, B Hall, JF Bastlund, et al.

  32. A response to claims of emergent intelligence and sentience in a dish

    Neuron, March 2, 2023

    F Balci, S Ben Hamed, T Boraud, S Bouret, T Brochier, C Brun, et al.

  33. A modular architecture for organizing, processing and sharing neurophysiology data

    Nat Methods, March 2, 2023

    International Brain Laboratory, N Bonacchi, GA Chapuis, Anne K. Churchland, EEJ DeWitt, M Faulkner, et al.

  34. Contrast and Luminance Gain Control in the Macaque's Lateral Geniculate Nucleus

    eNeuro, March 1, 2023

    RT Raghavan, JG Kelly, JM Hasse, PG Levy, MJ Hawken, and J. Anthony Movshon

  35. Neural Plasticity in Sensorimotor Brain-Machine Interfaces

    Annu Rev Biomed Eng, February 28, 2023

    MC Dadarlat, RA Canfield, and Amy Orsborn

  36. A searchable image resource of Drosophila GAL4-driver expression patterns with single neuron resolution

    Elife, February 23, 2023

    GW Meissner, A Nern, Z Dorman, GM DePasquale, K Forster, T Gibney, et al.

  37. Abstract representations emerge naturally in neural networks trained to perform multiple tasks

    Nat Commun, February 23, 2023

    WJ Johnston and Stefano Fusi

  38. A SPECT-based method for dynamic imaging of the glymphatic system in rats

    J Cereb Blood Flow Metab, February 21, 2023

    B Sigurdsson, NL Hauglund, TO Lilius, FL Mogensen, KN Mortensen, N Beschorner, et al.

  39. Encoding of dynamic facial information in the middle dorsal face area

    Proc Natl Acad Sci U S A., February 21, 2023

    Z Yang and Winrich Freiwald

  40. Macroscopic dynamics of neural networks with heterogeneous spiking thresholds

    Phys Rev E, February 16, 2023

    R Gast, Sara Solla, and A Kennedy

  41. Hypothalamic neurons that mirror aggression

    Cell, February 16, 2023

    T Yang, DW Bayless, Y Wei, D Landayan, IM Marcelo, Y Wang, et al.

  42. Mice and primates use distinct strategies for visual segmentation

    Elife, February 15, 2023

    FJ Luongo, L Liu, CLA Ho, JK Hesse, JB Wekselblatt, F Lanfranchi, et al.

  43. Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages

    Cell Stem Cell, February 10, 2023

    MF Wells, J Nemesh, S Ghosh, JM Mitchell, MR Salick, CJ Mello, et al.

  44. Anatomical biology guides a search for nutrients for the aging brain

    Mol Aspects Med, February 9, 2023

    V Lauriola, AM Lauriola, RP Sloan, and Scott Small

  45. Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation

    Elife, February 9, 2023

    RS Gomolka, LM Hablitz, H Mestre, M Giannetto, T Du, NL Hauglund, et al.

  46. Metacognitive computations for information search: Confidence in control

    Psychol Rev, February 9, 2023

    L Schulz, SM Fleming, and Peter Dayan

  47. Hypothalamic neurons that mirror aggression

    Cell, February 7, 2023

    T Yang, DW Bayless, Y Wei, D Landayan, IM Marcelo, Y Wang, et al.

  48. Glymphatic-assisted perivascular brain delivery of intrathecal small gold nanoparticles

    J Control Release, February 4, 2023

    TO Lilius, KN Mortensen, C Deville, TJ Lohela, FF Stæger, B Sigurdsson, et al.

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