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  1. A complete biomechanical model of Hydra contractile behaviors, from neural drive to muscle to movement.

    Publication

  2. Next-generation brain observatories

    Publication

  3. Dopamine neurons evaluate natural fluctuations in performance quality

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    Many motor skills are learned by comparing ongoing behavior to internal performance benchmarks. Dopamine neurons encode performance error in behavioral paradigms where error is externally induced, but it …

  4. Context-dependent representations of movement in Drosophila dopaminergic reinforcement pathways

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    Dopamine plays a central role in motivating and modifying behavior, serving to invigorate current behavioral performance and guide future actions through learning. Here we examine how this single …

  5. In Silico: Where Next?

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  6. The Mind of a Mouse

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    Large scientific projects in genomics and astronomy are influential not because they answer any single question but because they enable investigation of continuously arising new questions from the …

  7. Capturing Multiple Timescales of Adaptation to Second-Order Statistics With Generalized Linear Models: Gain Scaling and Fractional Differentiation

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    Single neurons can dynamically change the gain of their spiking responses to take into account shifts in stimulus variance. Moreover, gain adaptation can occur across multiple timescales. Here …

  8. Reconfiguring motor circuits for a joint manual and BCI task.

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    Designing brain-computer interfaces (BCIs) that can be used in conjunction with ongoing motor behavior requires an understanding of how neural activity co-opted for brain control interacts …

  9. The role of adaptation in neural coding.

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    The concept of 'neural coding' supposes that neural firing patterns in some sense represent some external correlate, whether sensory, motor, or structural knowledge about the world. While the …

  10. Visual-Olfactory Integration in the Human Disease Vector Mosquito Aedes aegypti.

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    Mosquitoes rely on the integration of multiple sensory cues, including olfactory, visual, and thermal stimuli, to detect, identify, and locate their hosts [1-4]. Although we increasingly know …

  11. Coding Principles in Adaptation.

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    Adaptation is a common principle that recurs throughout the nervous system at all stages of processing. This principle manifests in a variety of phenomena, from spike frequency adaptation …

  12. Fast and flexible sequence induction in spiking neural networks via rapid excitability changes

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    Cognitive flexibility likely depends on modulation of the dynamics underlying how biological neural networks process information. While dynamics can be reshaped by gradually modifying connectivity, less is known …

  13. Variation in sequence dynamics improves maintenance of stereotyped behavior in an example from bird song.

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    Performing a stereotyped behavior successfully over time requires both maintaining performance quality and adapting efficiently to environmental or physical changes affecting performance. The bird song system is a …

  14. Whither variability?

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  15. Multiple Timescales Account for Adaptive Responses across Sensory Cortices.

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    Sensory systems encounter remarkably diverse stimuli in the external environment. Natural stimuli exhibit timescales and amplitudes of variation that span a wide range. Mechanisms of adaptation, a ubiquitous …

  16. Editorial overview: Computational neuroscience.

    Publication

  17. Analysis of Neuronal Spike Trains, Deconstructed.

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    As information flows through the brain, neuronal firing progresses from encoding the world as sensed by the animal to driving the motor output of subsequent behavior. One of …