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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Sex-biasing influence of autism-associated Ube3a gene overdosage at connectomic, behavioral, and transcriptomic levels.

    Publication
  2. Sex-biasing influence of autism-associated Ube3a gene overdosage at connectomic, behavioral and transcriptomic levels.

    Publication
  3. D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans.

    Publication
  4. Abnormal whisker-dependent behaviors and altered cortico-hippocampal connectivity in Shank3b-/- mice.

    Publication
  5. Increased fMRI connectivity upon chemogenetic inhibition of the mouse prefrontal cortex.

    Publication
  6. Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes.

    Publication
  7. mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity.

    Publication
  8. Differences in subcortico-cortical interactions identified from connectome and microcircuit models in autism.

    Publication
  9. Microglia complement signaling promotes neuronal elimination and normal brain functional connectivity.

    Publication
  10. Regional, layer, and cell-type-specific connectivity of the mouse default mode network.

    Publication
  11. Acute and repeated intranasal oxytocin differentially modulate brain-wide functional connectivity.

    Publication
  12. Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women.

    Publication
  13. Animal functional magnetic resonance imaging: Trends and path toward standardization.

    Publication
  14. Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI analysis.

    Publication
  15. Towards neurosubtypes in autism.

    Publication
  16. Infraslow state fluctuations govern spontaneous fMRI network dynamics.

    Publication
  17. Deletion of autism risk gene Shank3 disrupts prefrontal connectivity.

    Publication
  18. Aberrant somatosensory processing and connectivity in mice lacking Engrailed-2.

    Publication
  19. Pharmacological inhibition of ERK signaling rescues pathophysiology and behavioral phenotype associated with 16p11.2 chromosomal deletion in mice.

    Publication
  20. Autism-associated 16p11.2 microdeletion impairs prefrontal functional connectivity in mouse and human.

    Publication
  21. Altered neocortical gene expression, brain overgrowth and functional over-connectivity in Chd8 haploinsufficient mice.

    Publication
  22. Brainwide mapping of endogenous serotonergic transmission via chemogenetic-fMRI.

    Publication
  23. The knockout of Synapsin II in mice impairs social behavior and functional connectivity generating an ASD-like phenotype.

    Publication
  24. Homozygous loss of autism-risk gene CNTNAP2 results in reduced local and long-range prefrontal functional connectivity.

    Publication
  25. Can mouse imaging studies bring order to autism connectivity chaos?

    Publication
  26. Altered functional connectivity networks in acallosal and socially impaired BTBR mice.

    Publication
  27. Functional connectivity hubs of the mouse brain.

    Publication
  28. Dysfunctional dopaminergic neurotransmission in asocial BTBR mice.

    Publication

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