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  1. Correcting motion induced fluorescence artifacts in two-channel neural imaging

    Publication
    … other methods of motion correction tested, the best of which were ~8x more accurate than control.

  2. A high-throughput method to deliver targeted optogenetic stimulation to moving C. elegans populations

    Publication
    We present a high-throughput optogenetic illumination system capable of simultaneous closed-loop light delivery to specified targets in populations of moving Caenorhabditis elegans. The instrument addresses three …

  3. Large-scale neural recordings call for new insights to link brain and behavior

    Publication
    Neuroscientists today can measure activity from more neurons than ever before, and are facing the challenge of connecting these brain-wide neural recordings to computation and behavior. In …

  4. A high-throughput method to deliver targeted optogenetic stimulation to moving C. elegans populations

    Publication
    We present a high-throughput optogenetic illumination system capable of simultaneous closed-loop light delivery to specified targets in populations of moving Caenorhabditis elegans. The instrument addresses three …

  5. Decoding locomotion from population neural activity in moving C. elegans

    Publication
    We investigated the neural representation of locomotion in the nematode C. elegans by recording population calcium activity during movement. We report that population activity more accurately decodes locomotion …

  6. Fast deep neural correspondence for tracking and identifying neurons in C. elegans using semi-synthetic training

    Publication
    We present an automated method to track and identify neurons in C. elegans, called 'fast Deep Neural Correspondence' or fDNC, based on the transformer network architecture. The model …

  7. Nonequilibrium Green's Functions for Functional Connectivity in the Brain

    Publication
    A theoretical framework describing the set of interactions between neurons in the brain, or functional connectivity, should include dynamical functions representing the propagation of signal from one neuron …

  8. Measuring and modeling whole-brain neural dynamics in Caenorhabditis elegans

    Publication
    The compact nervous system of the nematode Caenorhabditis elegans makes it a powerful playground to study how neural dynamics constrained by neuroanatomy generate neural function and behavior. The …

  9. Computational Neuroethology: A Call to Action.

    Publication
    The brain is worthy of study because it is in charge of behavior. A flurry of recent technical advances in measuring and quantifying naturalistic behaviors provide an important …

  10. Searching for collective behavior in a small brain.

    Publication
    In large neuronal networks, it is believed that functions emerge through the collective behavior of many interconnected neurons. Recently, the development of experimental techniques that allow simultaneous recording …

  11. Temporal processing and context dependency in C. elegans response to mechanosensation

    Publication
    A quantitative understanding of how sensory signals are transformed into motor outputs places useful constraints on brain function and helps reveal the brain's underlying computations. We investigate …