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  1. Dentate gyrus and CA3 GABAergic interneurons bidirectionally modulate signatures of internal and external drive to CA1

    Publication
    Specific classes of GABAergic neurons play specific roles in regulating information processing in the brain. In the hippocampus, two major classes, parvalbumin-expressing (PV+) and somatostatin-expressing (SST …

  2. Hippocampal replay of experience at real-world speeds

    Publication
    Representations related to past experiences play a critical role in memory and decision-making processes. The rat hippocampus expresses these types of representations during sharp-wave ripple (SWR …

  3. Hippocampal replay reflects specific past experiences rather than a plan for subsequent choice

    Publication
    Executing memory-guided behavior requires storage of information about experience and later recall of that information to inform choices. Awake hippocampal replay, when hippocampal neural ensembles briefly reactivate …

  4. Memory Alone Does Not Account for the Way Rats Learn a Simple Spatial Alternation Task

    Publication
    Animal behavior provides context for understanding disease models and physiology. However, that behavior is often characterized subjectively, creating opportunity for misinterpretation and misunderstanding. For example, spatial alternation tasks …

  5. Early Hippocampal Sharp-Wave Ripple Deficits Predict Later Learning and Memory Impairments in an Alzheimer's Disease Mouse Model.

    Publication
    Alzheimer's disease (AD) is characterized by progressive memory loss, and there is a pressing need to identify early pathophysiological alterations that predict subsequent memory impairment. Hippocampal sharp …

  6. Efficient Decoding of Multi-Dimensional Signals from Population Spiking Activity Using a Gaussian Mixture Particle Filter.

    Publication
    New recording technologies and the potential for closed-loop experiments have led to an increasing demand for computationally efficient and accurate algorithms to decode population spiking activity in …