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  1. Engulfment by brain macrophages in a short-lived vertebrate.

    Publication
    Engulfment by macrophages is critical for waste clearance in the vertebrate brain. Understanding clearance mechanisms may open new therapeutic possibilities to counter brain aging and neurodegenerative diseases. However …

  2. Lifelong behavioral screen reveals an architecture of vertebrate aging.

    Publication
    Mapping behavior of individual vertebrate animals across lifespan could provide an unprecedented view into the lifelong process of aging. We created a platform for high-resolution continuous behavioral …

  3. Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition.

    Publication
    The immune system could play an important role in the age-related decline in brain function, yet specific immune-based strategies to enhance brain resilience in older individuals …

  4. Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain

    Publication

  5. An automated feeding system for the African killifish reveals effects of dietary restriction on lifespan and allows scalable assessment of associative learning

    Publication

  6. Ageing and rejuvenation of tissue stem cells and their niches

    Publication
    Most adult organs contain regenerative stem cells, often organized in specific niches. Stem cell function is critical for tissue homeostasis and repair upon injury, and it is dependent …

  7. Meeting Report: Aging Research and Drug Discovery

    Publication
    Aging is the single largest risk factor for most chronic diseases, and thus possesses large socioeconomic interest to continuously aging societies. Consequently, the field of aging research is …

  8. Old and new models for the study of human ageing

    Publication
    Human ageing is associated with high susceptibility to disease. Some aspects of ageing can be studied directly in humans and have revealed that ageing is influenced by many …

  9. Aging and Rejuvenation of Neural Stem Cells and Their Niches

    Publication
    Aging has a profound and devastating effect on the brain. Old age is accompanied by declining cognitive function and enhanced risk of brain diseases, including cancer and neurodegenerative …

  10. Single-cell analysis reveals T cell infiltration in old neurogenic niches

    Publication
    The mammalian brain contains neurogenic niches that comprise neural stem cells and other cell types. Neurogenic niches become less functional with age, but how they change during ageing …

  11. Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses

    Publication
    Aging is accompanied by the functional decline of tissues. However, a systematic study of epigenomic and transcriptomic changes across tissues during aging is missing. Here, we generated chromatin …