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  1. Lack of accelerated ovarian aging in a follicle-stimulating hormone receptor haploinsufficiency mode

    Publication

  2. Differential Expression Analysis of Nothobranchius furzeri Transposable Elements from RNA-seq Data

    Publication

  3. Dynamic regulation of gonadal transposon control across the lifespan of the naturally short-lived African turquoise killifish

    Publication

  4. Differential Expression Analysis of Nothobranchius furzeri Transposable Elements from RNA-seq Data

    Publication

  5. Adult fibroblasts use aggresomes only in distinct cell-states

    Publication
    The aggresome is a protein turnover system in which proteins are trafficked along microtubules to the centrosome for degradation. Despite extensive focus on aggresomes in immortalized cell lines …

  6. Production of MHCII-expressing classical monocytes increases during aging in mice and humans

    Publication
    Aging is associated with increased monocyte production and altered monocyte function. Classical monocytes are heterogenous and a shift in their subset composition may underlie some of their apparent …

  7. Sex as a Biological Variable in Nutrition Research: From Human Studies to Animal Models

    Publication
    Biological sex is a fundamental source of phenotypic variability across species. Males and females have different nutritional needs and exhibit differences in nutrient digestion and utilization, leading to …

  8. Gentle Isolation of Nuclei from the Brain Tissue of Adult African Turquoise Killifish, a Naturally Short-Lived Model for Aging Research

    Publication
    Studying brain aging at single-cell resolution in vertebrate systems remains challenging due to cost, time, and technical constraints. Here, we demonstrate a protocol to generate single-nucleus …

  9. Single-cell RNA-seq of primary bone marrow neutrophils from female and male adult mice

    Publication
    Widespread sex-dimorphism is observed in the mammalian immune system. Consistently, studies have reported sex differences in the transcriptome of immune cells at the bulk level, including neutrophils …

  10. Protocol for analysis of mouse neutrophil NETosis by flow cytometry

    Publication
    Studies involving neutrophils are steadily increasing, thus creating a need for more optimized and thorough protocols for studying neutrophil function. Here, we present our protocol for extracting mouse …

  11. NHR-8 and P-glycoproteins uncouple xenobiotic resistance from longevity in chemosensory C. elegans mutants

    Publication
    Longevity is often associated with stress resistance, but whether they are causally linked is incompletely understood. Here we investigate chemosensory-defective Caenorhabditis elegans mutants that are long-lived …

  12. Multi-omic profiling of primary mouse neutrophils predicts a pattern of sex and age-related functional regulation

    Publication
    Neutrophils are the most abundant human white blood cell and constitute a first line of defense in the innate immune response. Neutrophils are short-lived cells, and thus …

  13. Functional genomics of inflamm-aging and immunosenescence

    Publication
    The aging population is at a higher risk for age-related diseases and infections. This observation could be due to immunosenescence: the decline in immune efficacy of both …

  14. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

    Publication
    Healthy aging can be promoted by enhanced metabolic fitness and physical capacity. Mitochondria are chief metabolic organelles with strong implications in aging that also coordinate broad physiological functions …

  15. Genome-wide surveillance of transcription errors in response to genotoxic stress

    Publication
    Mutagenic compounds are a potent source of human disease. By inducing genetic instability, they can accelerate the evolution of human cancers or lead to the development of genetically …

  16. The microbiome: an emerging key player in aging and longevity

    Publication
    Revolutionary advancements of high-throughput sequencing and metagenomic tools have provided new insights to microbiome function, including a bidirectional relationship between the microbiome and host aging. The intestinal …

  17. Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses

    Publication
    Aging is accompanied by the functional decline of tissues. However, a systematic study of epigenomic and transcriptomic changes across tissues during aging is missing. Here, we generated chromatin …