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  1. Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes

    Publication

  2. Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes

    Publication

  3. Microglia states and nomenclature: A field at its crossroads

    Publication

  4. Microglia states and nomenclature: A field at its crossroads

    Publication

  5. Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain

    Publication
    A key aspect of nearly all single-cell sequencing experiments is dissociation of intact tissues into single-cell suspensions. While many protocols have been optimized for optimal cell …

  6. The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease

    Publication
    Disruption of retromer-dependent endosomal trafficking is considered pathogenic in late-onset Alzheimer's disease (AD). Here, to investigate this disruption in the intact brain, we turn to …

  7. GABA-receptive microglia selectively sculpt developing inhibitory circuits.

    Publication

  8. Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice

    Publication
    The complement component 4 (C4) gene is linked to schizophrenia and synaptic refinement. In humans, greater expression of C4A in the brain is associated with an increased risk …

  9. Single-cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes.

    Publication

  10. Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

    Publication
    Microglia, the resident immune cells of the brain, rapidly change states in response to their environment, but we lack molecular and functional signatures of different microglial populations. Here …

  11. Microglia emerge as central players in brain disease.

    Publication

  12. Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression.

    Publication

  13. Microglia function during brain development: New insights from animal models.

    Publication