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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

  • All News
  • Research News
  • Funding Announcements
  • Newsletter Sign Up
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  • Media Relations

We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

  • Events Calendar
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  • Presidential Lectures
  • Presents
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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Extending the usefulness of the brief observation of social communication change (BOSCC): Validating the phrase speech and young fluent version.

    Publication
  2. Examining treatment outcomes across contexts: How do child baseline characteristics impact measurement of treatment response?

    Publication
  3. The brief observation of symptoms of autism (BOSA): Development of a new adapted assessment measure for remote telehealth administration through COVID-19 and beyond.

    Publication
  4. Genomic architecture of autism from comprehensive whole-genome sequence annotation.

    Publication
  5. Behavioral responses to fevers and other medical events in children with and without ASD.

    Publication
  6. Bias in measurement of autism symptoms by spoken language level and non-verbal mental age in minimally verbal children with neurodevelopmental disorders.

    Publication
  7. Intra-topic latency as an automated behavioral marker of treatment response in autism spectrum disorder.

    Publication
  8. The diagnosis of autism: From Kanner to DSM-III to DSM-5 and beyond.

    Publication
  9. Patterns and correlates of two-year changes in depressive symptoms for autistic adults.

    Publication
  10. Sex differences in scores on standardized measures of autism symptoms: A multisite integrative data analysis.

    Publication
  11. Detection of eye contact with deep neural networks is as accurate as human experts.

    Publication
  12. Language characterization in 16p11.2 deletion and duplication syndromes.

    Publication
  13. Autism spectrum disorder.

    Publication
  14. Sensitivity and specificity of early screening for autism.

    Publication
  15. How effective is LENA in detecting speech vocalizations and language produced by children and adolescents with ASD in different contexts?

    Publication
  16. Smartphone measures of day-to-day behavior changes in children with autism.

    Publication
  17. Simple, transparent, and flexible automated quality assessment procedures for ambulatory electrodermal activity data.

    Publication
  18. Damaging de novo mutations diminish motor skills in children on the autism spectrum.

    Publication
  19. Children with autism spectrum disorder who improve with fever: Insights from the Simons Simplex Collection.

    Publication
  20. Placebo-like response in absence of treatment in children with autism.

    Publication
  21. Increased eye contact during conversation compared to play in children with autism.

    Publication
  22. Subdimensions of social-communication impairment in autism spectrum disorder.

    Publication
  23. Replication of standardized ADOS domain scores in the Simons Simplex Collection.

    Publication
  24. Insights into autism spectrum disorder genomic architecture and biology from 71 risk loci.

    Publication
  25. A genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity?

    Publication
  26. Modest impact on risk for autism spectrum disorder of rare copy number variants at 15q11.2, specifically breakpoints 1 to 2.

    Publication
  27. The autism brain imaging data exchange: Towards a large-scale evaluation of the intrinsic brain architecture in autism.

    Publication
  28. Adjusting head circumference for covariates in autism: clinical correlates of a highly heritable continuous trait.

    Publication
  29. Subcategories of restricted and repetitive behaviors in children with autism spectrum disorders.

    Publication
  30. Effects of child characteristics on the Autism Diagnostic Interview-Revised: Implications for use of scores as a measure of ASD severity.

    Publication
  31. Factors influencing scores on the Social Responsiveness Scale.

    Publication
  32. Exploring the relationship between anxiety and insistence on sameness in autism spectrum disorders.

    Publication
  33. Common genetic variants, acting additively, are a major source of risk for autism.

    Publication
  34. Application of DSM-5 criteria for autism spectrum disorder to three samples of children with DSM-IV diagnoses of pervasive developmental disorders.

    Publication
  35. A multisite study of the clinical diagnosis of different autism spectrum disorders.

    Publication
  36. Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism.

    Publication
  37. The Simons Simplex Collection: a resource for identification of autism genetic risk factors.

    Publication
  38. A unified genetic theory for sporadic and inherited autism.

    Publication

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