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  1. Lipid packing and local geometry influence septin curvature sensing

    Publication
    Septins can assemble into scaffolds at the plasma membrane to regulate cell morphology. While septins preferentially bind convex membranes via amphipathic helices, their assembly on varied geometries in …

  2. Study of Protein-Protein Interactions in Septin Assembly: Multiple amphipathic helix domains cooperate in binding to the lipid membrane

    Publication
    Septins are a conserved family of cytoskeletal proteins known for sensing micron-scale membrane curvature via amphipathic helix (AH) domains. While cooperative interactions in septin assembly have been …

  3. Study of Protein-Protein Interactions in Septin Assembly: Multiple amphipathic helix domains cooperate in binding to the lipid membrane

    Publication
    Septins are a conserved family of cytoskeletal proteins known for sensing micron-scale membrane curvature via amphipathic helix (AH) domains. While cooperative interactions in septin assembly have been …

  4. Charge distribution and helicity tune the binding of septin's amphipathic helix domain to membranes

    Publication
    Amphipathic helices (AHs) are secondary structures that can facilitate binding of proteins to the membrane by folding into a helix with hydrophobic and hydrophilic faces that interact with …

  5. Charge distribution and helicity tune the binding of septin's amphipathic helix domain to membranes

    Publication
    Amphipathic helices (AHs) are secondary structures that can facilitate binding of proteins to the membrane by folding into a helix with hydrophobic and hydrophilic faces that interact with …

  6. OpenRAND: A performance portable, reproducible random number generation library for parallel computations

    Publication
    We introduce OpenRAND, a C++17 library aimed at facilitating reproducible scientific research by generating statistically robust yet replicable random numbers in as little as two lines of …

  7. Charge distribution and helical content tune the binding of septin’s amphipathic helix domain to lipid membranes

    Publication
    Septins are a class of cytoskeletal proteins that preferentially bind to domains of micron-scale curvature on the cell membrane. Studies have shown that amphipathic helix (AH) domains …

  8. The power of weak, transient interactions across biology: A paradigm of emergent behavior

    Publication
    A growing list of diverse biological systems and their equally diverse functionalities provides realizations of a paradigm of emergent behavior. In each of these biological systems, pervasive ensembles …