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The direct and indirect pathways of the basal ganglia are classically thought to promote and suppress action, respectively1. However, the observed co-activation of striatal direct and indirect …

Reward expectations based on internal knowledge of the external environment are a core component of adaptive behavior. However, internal knowledge may be inaccurate or incomplete due to errors …

Neural systems are remarkably robust against various perturbations, a phenomenon that still requires a clear explanation. Here, we graphically illustrate howneural networks can become robust. We study spiking …

Brain function relies on the coordination of activity across multiple, recurrently connected brain areas. For instance, sensory information encoded in early sensory areas is relayed to, and further …

The brain is composed of many functionally distinct areas. This organization supports distributed processing, and requires the coordination of signals across areas. Our understanding of how populations of …

Nearly all brain functions involve routing neural activity among a distributed network of areas. Understanding this routing requires more than a description of interareal anatomical connectivity: it requires …

Networks based on coordinated spike coding can encode information with high efficiency in the spike trains of individual neurons. These networks exhibit single-neuron variability and tuning curves …

A central tenet of neuroscience is that the brain works through large populations of interacting neurons. With recent advances in recording techniques, the inner working of these populations …

The accuracy of the neural code depends on the relative embedding of signal and noise in the activity of neural populations. Despite a wealth of theoretical work on …

Most brain functions involve interactions among multiple, distinct areas or nuclei. For instance, visual processing in primates requires the appropriate relaying of signals across many distinct cortical areas …