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  1. Oocyte mitophagy is critical for extended reproductive longevity

    Publication
    Women's reproductive cessation is the earliest sign of human aging and is caused by decreasing oocyte quality. Similarly, C. elegans' reproduction declines in mid-adulthood and is …

  2. Novel elasticity measurements reveal C. elegans cuticle stiffens with age and in a long-lived mutant

    Publication
    Changes in biomechanical properties have profound impacts on human health. C. elegans might serve as a model for studying the molecular genetics of mammalian tissue decline. Previously, we …

  3. CeAid: a smartphone application for logging and plotting Caenorhabditis elegans assays

    Publication
    Caenorhabditis elegans is used as a model organism to study a wide range of topics in molecular and cellular biology. Conventional C. elegans assays often require a large …

  4. The role of the Cer1 transposon in horizontal transfer of transgenerational memory

    Publication
    Animals face both external and internal dangers: pathogens threaten from the environment, and unstable genomic elements threaten from within. C. elegans protects itself from pathogens by "reading" bacterial …

  5. Oleic Acid Protects Caenorhabditis Mothers From Mating-Induced Death and the Cost of Reproduction

    Publication

  6. Sex and death

    Publication
    Sexual interactions negatively impact health and longevity in many species across the animal kingdom. C. elegans has been established as a good model to study how mating and …

  7. Reduced insulin/IGF1 signaling prevents immune aging via ZIP-10/bZIP-mediated feedforward loop

    Publication
    A hallmark of aging is immunosenescence, a decline in immune functions, which appeared to be inevitable in living organisms, including Caenorhabditis elegans. Here, we show that genetic inhibition …

  8. Protocol for transgenerational learned pathogen avoidance behavior assays in Caenorhabditis elegans

    Publication
    Animal experiences, including learned behaviors, can be passed down to several generations of progeny in a phenomenon known as transgenerational epigenetic inheritance. Yet, little is known regarding the …

  9. Metformin rescues Parkinson's disease phenotypes caused by hyperactive mitochondria

    Publication
    Metabolic dysfunction occurs in many age-related neurodegenerative diseases, yet its role in disease etiology remains poorly understood. We recently discovered a potential causal link between the branched …