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  1. Oculomotor plant and neural dynamics suggest gaze control requires integration on distributed timescales

    Publication
    … integrator. Here we use measurements from new and published experiments in the larval zebrafish together with modelling to reconcile recent oculomotor plant observations with oculomotor integrator function …

  2. Multiple timescales of sensory-evidence accumulation across the dorsal cortex

    Publication
    Cortical areas seem to form a hierarchy of intrinsic timescales, but the relevance of this organization for cognitive behavior remains unknown. In particular, decisions requiring the gradual accrual …

  3. Detecting and correcting false transients in calcium imaging

    Publication
    Population recordings of calcium activity are a major source of insight into neural function. Large datasets require automated processing, but this can introduce errors that are difficult to …

  4. Novel stimuli evoke excess activity in the mouse primary visual cortex

    Publication
    o explore how neural circuits represent novel versus familiar inputs, we presented mice with repeated sets of images with novel images sparsely substituted. Using two-photon calcium imaging …

  5. Sequential and efficient neural-population coding of complex task information

    Publication
    Recent work has highlighted that many types of variables are represented in each neocortical area. How can these many neural representations be organized together without interference and coherently …

  6. Geometry of abstract learned knowledge in the hippocampus

    Publication

  7. Neural Anatomy and Optical Microscopy (NAOMi) Simulation for evaluating calcium imaging methods

    Publication
    Background: The past decade has seen a multitude of new in vivo functional imaging methodologies. However, the lack of ground-truth comparisons or evaluation metrics makes the large …

  8. Amplitude modulations of cortical sensory responses in pulsatile evidence accumulation

    Publication
    How does the brain internally represent a sequence of sensory information that jointly drives a decision-making behavior? Studies of perceptual decision-making have often assumed that sensory …

  9. The Mind of a Mouse

    Publication
    Large scientific projects in genomics and astronomy are influential not because they answer any single question but because they enable investigation of continuously arising new questions from the …

  10. Visual cue-related activity of cells in the medial entorhinal cortex during navigation in virtual reality.

    Publication
    During spatial navigation, animals use self-motion to estimate positions through path integration. However, estimation errors accumulate over time and it is unclear how they are corrected. Here …

  11. Coarse Graining, Fixed Points, and Scaling in a Large Population of Neurons

    Publication
    We develop a phenomenological coarse-graining procedure for activity in a large network of neurons, and apply this to recordings from a population of 1000+ cells in the …

  12. Task-Dependent Changes in the Large-Scale Dynamics and Necessity of Cortical Regions

    Publication
    Neural activity throughout the cortex is correlated with perceptual decisions, but inactivation studies suggest that only a small number of areas are necessary for these behaviors. Here we …

  13. Cerebellar disruption impairs working memory during evidence accumulation.

    Publication
    To select actions based on sensory evidence, animals must create and manipulate representations of stimulus information in memory. Here we report that during accumulation of somatosensory evidence, optogenetic …

  14. Specialized coding of sensory, motor and cognitive variables in VTA dopamine neurons

    Publication
    There is increased appreciation that dopamine neurons in the midbrain respond not only to reward1 and reward-predicting cues1,2, but also to other variables such as the …

  15. CaImAn an open source tool for scalable calcium imaging data analysis.

    Publication
    Advances in fluorescence microscopy enable monitoring larger brain areas in-vivo with finer time resolution. The resulting data rates require reproducible analysis pipelines that are reliable, fully automated …

  16. Imaging Cortical Dynamics in GCaMP Transgenic Rats with a Head-Mounted Widefield Macroscope.

    Publication
    Widefield imaging of calcium dynamics is an emerging method for mapping regional neural activity but is currently limited to restrained animals. Here we describe cScope, a head-mounted …

  17. A Map-like Micro-Organization of Grid Cells in the Medial Entorhinal Cortex

    Publication
    How the topography of neural circuits relates to their function remains unclear. Although topographic maps exist for sensory and motor variables, they are rarely observed for cognitive variables …

  18. A Dedicated Population for Reward Coding in the Hippocampus

    Publication
    The hippocampus plays a critical role in goal-directed navigation. Across different environments, however, hippocampal maps are randomized, making it unclear how goal locations could be encoded consistently …

  19. An Accumulation-of-Evidence Task Using Visual Pulses for Mice Navigating in Virtual Reality.

    Publication
    The gradual accumulation of sensory evidence is a crucial component of perceptual decision making, but its neural mechanisms are still poorly understood. Given the wide availability of genetic …