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  1. Neural circuits underlying habituation of visually evoked escape behaviors in larval zebrafish

    Publication

  2. Social isolation modulates appetite and avoidance behavior via a common oxytocinergic circuit in larval zebrafish

    Publication
    Animal brains have evolved to encode social stimuli and transform these representations into advantageous behavioral responses. The commonalities and differences of these representations across species are not well …

  3. Voltage imaging identifies spinal circuits that modulate locomotor adaptation in zebrafish

    Publication
    Motor systems must continuously adapt their output to maintain a desired trajectory. While the spinal circuits underlying rhythmic locomotion are well described, little is known about how the …

  4. Distributed chromatic processing at the interface between retina and brain in the larval zebrafish

    Publication
    Larval zebrafish (Danio rerio) are an ideal organism for studying color vision, as their retina possesses four types of cone photoreceptors, covering most of the visible range and …

  5. Larval Zebrafish Use Olfactory Detection of Sodium and Chloride to Avoid Salt Water

    Publication
    Salinity levels constrain the habitable environment of all aquatic organisms. Zebrafish are freshwater fish that cannot tolerate high-salt environments and would therefore benefit from neural mechanisms that …

  6. Cerebellar Neurodynamics Predict Decision Timing and Outcome on the Single-Trial Level.

    Publication
    Goal-directed behavior requires the interaction of multiple brain regions. How these regions and their interactions with brain-wide activity drive action selection is less understood. We have …

  7. Probabilistic Models of Larval Zebrafish Behavior Reveal Structure on Many Scales.

    Publication
    Nervous systems have evolved to combine environmental information with internal state to select and generate adaptive behavioral sequences. To better understand these computations and their implementation in neural …

  8. Neural circuits for evidence accumulation and decision making in larval zebrafish.

    Publication
    To make appropriate decisions, animals need to accumulate sensory evidence. Simple integrator models can explain many aspects of such behavior, but how the underlying computations are mechanistically implemented …

  9. Elements of a stochastic 3D prediction engine in larval zebrafish prey capture.

    Publication
    The computational principles underlying predictive capabilities in animals are poorly understood. Here, we wondered whether predictive models mediating prey capture could be reduced to a simple set of …

  10. A bidirectional network for appetite control in larval zebrafish.

    Publication
    Medial and lateral hypothalamic loci are known to suppress and enhance appetite, respectively, but the dynamics and functional significance of their interaction have yet to be explored. Here …

  11. Convergent Temperature Representations in Artificial and Biological Neural Networks

    Publication
    Discoveries in biological neural networks (BNNs) shaped artificial neural networks (ANNs) and computational parallels between ANNs and BNNs have recently been discovered. However, it is unclear to what …

  12. Zebrafish oxytocin neurons drive nocifensive behavior via brainstem premotor targets

    Publication
    Animals have evolved specialized neural circuits to defend themselves from pain- and injury-causing stimuli. Using a combination of optical, behavioral and genetic approaches in the larval zebrafish …

  13. Brain-wide Organization of Neuronal Activity and Convergent Sensorimotor Transformations in Larval Zebrafish.

    Publication
    Simultaneous recordings of large populations of neurons in behaving animals allow detailed observation of high-dimensional, complex brain activity. However, experimental approaches often focus on singular behavioral paradigms …

  14. A Brain-wide Circuit Model of Heat-Evoked Swimming Behavior in Larval Zebrafish

    Publication
    Thermosensation provides crucial information, but how temperature representation is transformed from sensation to behavior is poorly understood. Here, we report a preparation that allows control of heat delivery …

  15. Expansion microscopy of zebrafish for neuroscience and developmental biology studies.

    Publication
    Expansion microscopy (ExM) allows scalable imaging of preserved 3D biological specimens with nanoscale resolution on fast diffraction-limited microscopes. Here, we explore the utility of ExM in the …

  16. Gaze-stabilizing central vestibular neurons project asymmetrically to extraocular motoneuron pools.

    Publication
    … compromising reflexive behavior.SIGNIFICANCE STATEMENTInterneuron populations use specific anatomical projections to transform sensations into reflexive actions. Here we examined how the anatomical composition of a genetically-defined …

  17. A novel mechanism for mechanosensory-based rheotaxis in larval zebrafish.

    Publication
    When flying or swimming, animals must adjust their own movement to compensate for displacements induced by the flow of the surrounding air or water. These flow-induced displacements …