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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

  • All News
  • Research News
  • Funding Announcements
  • Newsletter Sign Up
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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

  • Events Calendar
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  • Presidential Lectures
  • Presents
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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  • Simons Collaboration on Localization of Waves
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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans.

    Publication
  2. Combinatorial targeting of distributed forebrain networks reverses noise hypersensitivity in a model of autism spectrum disorder.

    Publication
  3. Targeting peripheral somatosensory neurons to improve tactile-related phenotypes in ASD models.

    Publication
  4. Neuronal deletion of Gtf2i, associated with Williams syndrome, causes behavioral and myelin alterations rescuable by a remyelinating drug.

    Publication
  5. Thalamic reticular dysfunction as a circuit endophenotype in neurodevelopmental disorders.

    Publication
  6. CHD8 mutation leads to autistic-like behaviors and impaired striatal circuits.

    Publication
  7. SHANK proteins: Roles at the synapse and in autism spectrum disorder.

    Publication
  8. A viral strategy for targeting and manipulating interneurons across vertebrate species.

    Publication
  9. Transgenic labeling of parvalbumin-expressing neurons with tdTomato.

    Publication
  10. Neurobiology of social behavior abnormalities in autism and Williams syndrome.

    Publication
  11. Thalamic reticular impairment underlies attention deficit in PTCHD1Y/- mice.

    Publication
  12. Adult restoration of SHANK3 expression rescues selective autistic-like phenotypes.

    Publication
  13. Mice with Shank3 mutations associated with ASD and schizophrenia display both shared and distinct defects.

    Publication
  14. CRISPR-CAS9 knockin mice for genome editing and cancer modeling.

    Publication
  15. Circuit-selective striatal synaptic dysfunction in the SAPAP3 knockout mouse model of obsessive-compulsive disorder.

    Publication
  16. Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors.

    Publication
  17. Cellular and synaptic network defects in autism.

    Publication
  18. Functional consequences of mutations in postsynaptic scaffolding proteins and relevance to psychiatric disorders.

    Publication
  19. Neurobiology of obsessive-compulsive disorder: Insights into neural circuitry dysfunction through mouse genetics.

    Publication
  20. Shank3 mutant mice display autistic-like behaviours and striatal dysfunction.

    Publication

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