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  1. A neural substrate of sex-dependent modulation of motivation

    Publication

  2. Behavioural and dopaminergic signatures of resilience

    Publication

  3. Cholinergic interneurons mediate cocaine extinction in male mice through plasticity across medium spiny neuron subtypes

    Publication
    Cholinergic interneurons (ChINs) in the nucleus accumbens (NAc) have been implicated in the extinction of drug associations, as well as related plasticity in medium spiny neurons (MSNs). However …

  4. Choice-selective sequences dominate in cortical relative to thalamic inputs to NAc to support reinforcement learning

    Publication
    How are actions linked with subsequent outcomes to guide choices? The nucleus accumbens, which is implicated in this process, receives glutamatergic inputs from the prelimbic cortex and midline …

  5. Cholinergic interneurons mediate cocaine extinction in male mice through plasticity across medium spiny neuron subtypes

    Publication
    Cholinergic interneurons (ChINs) in the nucleus accumbens (NAc) have been implicated in the extinction of drug associations, as well as related plasticity in medium spiny neurons (MSNs). However …

  6. Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state

    Publication
    A classic view of the striatum holds that activity in direct and indirect pathways oppositely modulates motor output. Whether this involves direct control of movement, or reflects a …

  7. A Comparison of Dopaminergic and Cholinergic Populations Reveals Unique Contributions of VTA Dopamine Neurons to Short-Term Memory

    Publication
    We systematically compare the contributions of two dopaminergic and two cholinergic ascending populations to a spatial short-term memory task in rats. In ventral tegmental area dopamine (VTA …

  8. Inferring spikes from calcium imaging in dopamine neurons

    Publication

  9. Standardized and reproducible measurement of decision-making in mice

    Publication
    Progress in science requires standardized assays whose results can be readily shared, compared, and reproduced across laboratories. Reproducibility, however, has been a concern in neuroscience, particularly for measurements …

  10. A Comparison of Dopaminergic and Cholinergic Populations Reveals Unique Contributions of VTA Dopamine Neurons to Short-Term Memory

    Publication
    We systematically compare the contributions of two dopaminergic and two cholinergic ascending populations to a spatial short-term memory task in rats. In ventral tegmental area dopamine (VTA …

  11. Distinct signals in medial and lateral VTA dopamine neurons modulate fear extinction at different times

    Publication
    Dopamine (DA) neurons are to encode reward prediction error (RPE), in addition to other signals, such as salience. While RPE is known to support learning, the role of …

  12. Striatal circuits for reward learning and decision-making

    Publication
    The striatum is essential for learning which actions lead to reward and for implementing those actions. Decades of experimental and theoretical work have led to several influential theories …

  13. Specialized coding of sensory, motor and cognitive variables in VTA dopamine neurons

    Publication
    There is increased appreciation that dopamine neurons in the midbrain respond not only to reward1 and reward-predicting cues1,2, but also to other variables such as the …

  14. Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons.

    Publication
    Although midbrain dopamine (DA) neurons have been thought to primarily encode reward prediction error (RPE), recent studies have also found movement-related DAergic signals. For example, we recently …

  15. Dopamine Modulation of Prefrontal Cortex Activity Is Manifold and Operates at Multiple Temporal and Spatial Scales.

    Publication
    Although the function of dopamine in subcortical structures is largely limited to reward and movement, dopamine neurotransmission in the prefrontal cortex (PFC) is critical to a multitude of …

  16. An Accumulation-of-Evidence Task Using Visual Pulses for Mice Navigating in Virtual Reality.

    Publication
    The gradual accumulation of sensory evidence is a crucial component of perceptual decision making, but its neural mechanisms are still poorly understood. Given the wide availability of genetic …

  17. Combined Social and Spatial Coding in a Descending Projection from the Prefrontal Cortex.

    Publication
    Social behaviors are crucial to all mammals. Although the prelimbic cortex (PL, part of medial prefrontal cortex) has been implicated in social behavior, it is not clear which …

  18. Modular organization of the brainstem noradrenaline system coordinates opposing learning states.

    Publication
    Noradrenaline modulates global brain states and diverse behaviors through what is traditionally believed to be a homogeneous cell population in the brainstem locus coeruleus (LC). However, it is …