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  1. The physical consequences of sperm gigantism

    Publication
    Males of the fruit fly Drosophila melanogaster produce sperm that are each, on average, a couple of millimetres long. Thousands of sperm are stored in a seminal vesicle …

  2. The physical consequences of sperm gigantism

    Publication
    The male fruit fly produces ~1.8 mm long sperm, thousands of which can be stored until mating in a ~200 micron sac, the seminal vesicle. While the …

  3. To be or not to be: orb, the fusome and oocyte specification in Drosophila

    Publication
    In the fruit fly Drosophila melanogaster, two cells in a cyst of 16 interconnected cells have the potential to become the oocyte, but only one of these will …

  4. Scaling behaviour and control of nuclear wrinkling

    Publication
    The cell nucleus is enveloped by a complex membrane, whose wrinkling has been implicated in disease and cellular aging. The biophysical dynamics and spectral evolution of nuclear wrinkling …

  5. Fusome topology and inheritance during insect gametogenesis

    Publication
    From insects to mammals, oocytes and sperm develop within germline cysts comprising cells connected by intercellular bridges (ICBs). In numerous insects, formation of the cyst is accompanied by …

  6. Dynamics, scaling behavior, and control of nuclear wrinkling

    Publication
    The cell nucleus is enveloped by a complex membrane, whose wrinkling has been implicated in disease and cellular aging. The biophysical dynamics and spectral evolution of nuclear wrinkling …

  7. Mechanics of stabilized intercellular bridges

    Publication
    Numerous engineered and natural systems form through reinforcement and stabilization of a deformed configuration that was generated by a transient force. An important class of such structures arises …

  8. Quantitative models for building and growing fated small cell networks

    Publication
    Small cell clusters exhibit numerous phenomena typically associated with complex systems, such as division of labour and programmed cell death. A conserved class of such clusters occurs during …

  9. Sex-specific topological differences in germline cell lineage trees

    Publication
    A conserved phase of gametogenesis is the development of oocytes and sperm within cell clusters (germline cysts) that arise through serial divisions of a founder cell. The resulting …

  10. Mapping parameter spaces of biological switches

    Publication
    Since the seminal 1961 paper of Monod and Jacob, mathematical models of biomolecular circuits have guided our understanding of cell regulation. Model-based exploration of the functional capabilities …