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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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  • Funding Announcements
  • Newsletter Sign Up
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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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  • Presidential Lectures
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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  • Simons Collaboration on Localization of Waves
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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes.

    Publication
  2. Placental endocrine function shapes cerebellar development and social behavior.

    Publication
  3. Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling.

    Publication
  4. Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development.

    Publication
  5. Large-scale analyses of the relationship between sex, age and intelligence quotient heterogeneity and cortical morphometry in autism spectrum disorder.

    Publication
  6. Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI analysis.

    Publication
  7. Leveraging biobank-scale rare and common variant analyses to identify ASPHD1 as the main driver of reproductive traits in the 16p11.2 locus.

    Publication
  8. Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions.

    Publication
  9. Altered neocortical gene expression, brain overgrowth and functional over-connectivity in Chd8 haploinsufficient mice.

    Publication
  10. Foxp1 in forebrain pyramidal neurons controls gene expression required for spatial learning and synaptic plasticity.

    Publication
  11. Foxp1 regulation of neonatal vocalizations via cortical development.

    Publication
  12. Neuronal overexpression of Ube3a isoform 2 causes behavioral impairments and neuroanatomical pathology relevant to 15q11.2-q13.3 duplication syndrome.

    Publication
  13. Neuroanatomy in mouse models of Rett syndrome is related to the severity of Mecp2 mutation and behavioral phenotypes.

    Publication
  14. Language ability predicts cortical structure and covariance in boys with autism spectrum disorder.

    Publication
  15. Prenatal beta-catenin/BRN2/TBR2 transcriptional cascade regulates adult social and stereotypic behaviors.

    Publication
  16. Structural gray matter differences during childhood development in autism spectrum disorder: A multimetric approach.

    Publication
  17. Clustering autism: Using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity.

    Publication
  18. Behavioral abnormalities and circuit defects in the basal ganglia of a mouse model of 16p11.2 deletion syndrome.

    Publication
  19. Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism.

    Publication

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