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  1. Action suppression reveals opponent parallel control via striatal circuits

    Publication
    The direct and indirect pathways of the basal ganglia are classically thought to promote and suppress action, respectively1. However, the observed co-activation of striatal direct and indirect …

  2. Efficient coding of cognitive variables underlies dopamine response and choice behavior

    Publication
    Reward expectations based on internal knowledge of the external environment are a core component of adaptive behavior. However, internal knowledge may be inaccurate or incomplete due to errors …

  3. The Neural Basis of Timing: Distributed Mechanisms for Diverse Functions.

    Publication
    Timing is critical to most forms of learning, behavior, and sensory-motor processing. Converging evidence supports the notion that, precisely because of its importance across a wide range …

  4. The many worlds hypothesis of dopamine prediction error: implications of a parallel circuit architecture in the basal ganglia.

    Publication
    Computational models of reinforcement learning (RL) strive to produce behavior that maximises reward, and thus allow software or robots to behave adaptively [1]. At the core of RL …

  5. High-Yield Methods for Accurate Two-Alternative Visual Psychophysics in Head-Fixed Mice.

    Publication
    Research in neuroscience increasingly relies on the mouse, a mammalian species that affords unparalleled genetic tractability and brain atlases. Here, we introduce high-yield methods for probing mouse …

  6. Distinct Roles for the Amygdala and Orbitofrontal Cortex in Representing the Relative Amount of Expected Reward.

    Publication
    The same reward can possess different motivational meaning depending upon its magnitude relative to other rewards. To study the neurophysiological mechanisms mediating assignment of motivational meaning, we recorded …