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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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  • Newsletter Sign Up
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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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  • Presidential Lectures
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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. 2 Simons Foundation Investigators Elected to the National Academy of Medicine

    November 3, 2025
    This year’s new cohort of National Academy of Medicine members includes two investigators funded by the Simons Foundation. Election to the academy “recognizes individuals who have demonstrated …
  2. Scoring the Brain: How Benchmark Datasets and Other Tools Are Solving Key Challenges in Neuroscience

    August 25, 2021
    With standardized datasets, community-building challenges and simplified software bundles, research initiatives strive to bring uniformity to analysis in neuroscience.
  3. The Connected Connectome Part 2: Beyond the Fly

    March 22, 2021
    Success in flies and worms has inspired several efforts to reconstruct more complex mammalian brain circuits. Reconstructing a whole mouse brain using electron microscopy is the next logical …
  4. Tracking Information Across the Brain

    May 28, 2020
    As we think, information is routed all over the brain, undergoing a complex series of transformations. Successful tracking of those transformations may help scientists decipher the brain’s …
  5. Sculpting Light: Designing Optimal All-Optical Experiments

    January 29, 2020
    As the technology to control groups of neurons matures, researchers are trying to figure out how to use it to answer neuroscience’s big questions.
  6. Searching for the Root of Short-Term Memory

    December 17, 2019
    Karel Svoboda aims to understand how neural circuits give rise to sustained activity, the neural correlate of short-term memory.
  7. Why Neurophysiology Needs an MP3

    October 2, 2019
    When it comes to data sharing, neuroscience lags behind many other fields. But a growing number of large-scale projects are inspiring new efforts to develop workable tools.
  8. How the Brain Holds On to Working Memory

    March 15, 2019
    How do neural circuits hold on to an idea even though individual neurons only fire within milliseconds after stimulation? So-called attractor dynamics may explain memory-related activity.
  9. A New Effort To Standardize Neurophysiology Data

    September 11, 2017
    Neurodata Without Borders wants to transform the field by making it easier to share research.
  10. Working-Memory Research Uncovers Essential Role for Thalamus

    June 27, 2017
    Previous research suggests that the neural signals underlying working memory reside in the cortex. But the new findings suggest the thalamus is a vital contributor.
  11. New Genetically Engineered Sensors Enhance Brain-Wide Monitoring

    February 15, 2017
    Experimental evolution enables scientists to create better calcium and voltage sensors.
  12. Neuroscience in a Global Era: What Are the Best Ways To Collaborate?

    November 24, 2016
    Amid an onslaught of large-scale neuroscience projects, a special issue of Neuron explores how neuroscientists can work together more effectively and how to leverage new technologies.
  13. 7 Simons-Supported Researchers and Advisory Board Member Elected to the National Academy of Sciences

    April 30, 2015
    … melanogaster flies, mosquitoes and people, Vosshall’s research has yielded new knowledge about how odor stimuli are processed and perceived. Finally, Simons Foundation co-founder Jim Simons …

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