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  1. Fast and sensitive GCaMP calcium indicators for imaging neural populations

    Publication

  2. A response to claims of emergent intelligence and sentience in a dish

    Publication

  3. Next-generation brain observatories

    Publication

  4. The Neurodata Without Borders ecosystem for neurophysiological data science

    Publication

  5. Neural Algorithms and Circuits for Motor Planning

    Publication
    The brain plans and executes volitional movements. The underlying patterns of neural population activity have been explored in the context of movements of the eyes, limbs, tongue, and …

  6. A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement

    Publication
    Motor behaviors are often planned long before execution but only released after specific sensory events. Planning and execution are each associated with distinct patterns of motor cortex activity …

  7. A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement

    Publication
    Motor behaviors are often planned long before execution but only released after specific sensory events. Planning and execution are each associated with distinct patterns of motor cortex activity …

  8. A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement

    Publication
    Motor behaviors are often planned long before execution but only released after specific sensory events. Planning and execution are each associated with distinct patterns of motor cortex activity …

  9. Accurate Localization of Linear Probe Electrode Arrays across Multiple Brains

    Publication
    Recently developed probes for extracellular electrophysiological recordings have large numbers of electrodes on long linear shanks. Linear electrode arrays, such as Neuropixels probes, have hundreds of recording electrodes …

  10. Attractor dynamics gate cortical information flow during decision-making

    Publication
    Decisions are held in memory until enacted, which makes them potentially vulnerable to distracting sensory input. Gating of information flow from sensory to motor areas could protect memory …

  11. High-fidelity estimates of spikes and subthreshold waveforms from 1-photon voltage imaging in vivo

    Publication
    The ability to probe the membrane potential of multiple genetically defined neurons simultaneously would have a profound impact on neuroscience research. Genetically encoded voltage indicators are a promising …

  12. Targeted photostimulation uncovers circuit motifs supporting short-term memory

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    Short-term memory is associated with persistent neural activity that is maintained by positive feedback between neurons. To explore the neural circuit motifs that produce memory-related persistent …

  13. The Mind of a Mouse

    Publication
    Large scientific projects in genomics and astronomy are influential not because they answer any single question but because they enable investigation of continuously arising new questions from the …

  14. A comparison of neuronal population dynamics measured with calcium imaging and electrophysiology

    Publication
    Calcium imaging with fluorescent protein sensors is widely used to record activity in neuronal populations. The transform between neural activity and calcium-related fluorescence involves nonlinearities and low …

  15. Rapid mesoscale volumetric imaging of neural activity with synaptic resolution.

    Publication
    Imaging neurons and neural circuits over large volumes at high speed and subcellular resolution is a difficult task. Incorporating a Bessel focus module into a two-photon fluorescence …

  16. Recurrent interactions in local cortical circuits.

    Publication
    Most cortical synapses are local and excitatory. Local recurrent circuits could implement amplification, allowing pattern completion and other computations1-4. Cortical circuits contain subnetworks that consist of neurons …

  17. Spatiotemporal constraints on optogenetic inactivation in cortical circuits.

    Publication
    Optogenetics allows manipulations of genetically and spatially defined neuronal populations with excellent temporal control. However, neurons are coupled with other neurons over multiple length scales, and the effects …

  18. Functional clustering of dendritic activity during decision-making.

    Publication
    The active properties of dendrites can support local nonlinear operations, but previous imaging and electrophysiological measurements have produced conflicting views regarding the prevalence and selectivity of local nonlinearities …

  19. Reconstruction of 1,000 Projection Neurons Reveals New Cell Types and Organization of Long-Range Connectivity in the Mouse Brain.

    Publication
    Neuronal cell types are the nodes of neural circuits that determine the flow of information within the brain. Neuronal morphology, especially the shape of the axonal arbor, provides …

  20. Recruitment of GABAergic Interneurons in the Barrel Cortex during Active Tactile Behavior

    Publication
    Neural computation involves diverse types of GABAergic inhibitory interneurons that are integrated with excitatory (E) neurons into precisely structured circuits. To understand how each neuron type shapes sensory …

  21. Recruitment of GABAergic Interneurons in the Barrel Cortex during Active Tactile Behavior.

    Publication
    Neural computation involves diverse types of GABAergic inhibitory interneurons that are integrated with excitatory (E) neurons into precisely structured circuits. To understand how each neuron type shapes sensory …

  22. Kilohertz frame-rate two-photon tomography.

    Publication
    Point-scanning two-photon microscopy enables high-resolution imaging within scattering specimens such as the mammalian brain, but sequential acquisition of voxels fundamentally limits its speed. We developed …

  23. Bright and photostable chemigenetic indicators for extended in vivo voltage imaging.

    Publication
    Genetically encoded voltage indicators (GEVIs) enable monitoring of neuronal activity at high spatial and temporal resolution. However, the utility of existing GEVIs has been limited by the brightness …

  24. High-performance calcium sensors for imaging activity in neuronal populations and microcompartments.

    Publication
    Calcium imaging with genetically encoded calcium indicators (GECIs) is routinely used to measure neural activity in intact nervous systems. GECIs are frequently used in one of two different …

  25. Discrete attractor dynamics underlies persistent activity in the frontal cortex.

    Publication
    Short-term memories link events separated in time, such as past sensation and future actions. Short-term memories are correlated with slow neural dynamics, including selective persistent activity …

  26. An orderly single-trial organization of population dynamics in premotor cortex predicts behavioral variability

    Publication
    Animals are not simple input-output machines. Their responses to even very similar stimuli are variable. A key, long-standing question in neuroscience is to understand the neural …

  27. Shared and distinct transcriptomic cell types across neocortical areas.

    Publication
    The neocortex contains a multitude of cell types that are segregated into layers and functionally distinct areas. To investigate the diversity of cell types across the mouse neocortex …

  28. Distinct descending motor cortex pathways and their roles in movement.

    Publication
    Activity in the motor cortex predicts movements, seconds before they are initiated. This preparatory activity has been observed across cortical layers, including in descending pyramidal tract neurons in …

  29. A cortico-cerebellar loop for motor planning

    Publication
    Persistent and ramping neural activity in the frontal cortex anticipates specific movements. Preparatory activity is distributed across several brain regions, but it is unclear which brain areas are …

  30. Thy1 transgenic mice expressing the red fluorescent calcium indicator jRGECO1a for neuronal population imaging in vivo.

    Publication
    Calcium imaging is commonly used to measure the neural activity of large groups of neurons in mice. Genetically encoded calcium indicators (GECIs) can be delivered for this purpose …

  31. Genetic Dissection of Neural Circuits: A Decade of Progress

    Publication
    Tremendous progress has been made since Neuron published our Primer on genetic dissection of neural circuits 10 years ago. Since then, cell-type-specific anatomical, neurophysiological, and perturbation …

  32. Low-dimensional and monotonic preparatory activity in mouse anterior lateral motor cortex.

    Publication
    Neurons in multiple brain regions fire trains of action potentials anticipating specific movements, but this "preparatory activity" has not been systematically compared across behavioral tasks. We compared preparatory …

  33. Neural mechanisms of movement planning: motor cortex and beyond.

    Publication
    Neurons in motor cortex and connected brain regions fire in anticipation of specific movements, long before movement occurs. This neural activity reflects internal processes by which the brain …

  34. Fully integrated silicon probes for high-density recording of neural activity.

    Publication
    Sensory, motor and cognitive operations involve the coordinated action of large neuronal populations across multiple brain regions in both superficial and deep structures. Existing extracellular probes record neural …

  35. Mechanisms underlying a thalamocortical transformation during active tactile sensation

    Publication
    During active somatosensation, neural signals expected from movement of the sensors are suppressed in the cortex, whereas information related to touch is enhanced. This tactile suppression underlies low …

  36. A Map of Anticipatory Activity in Mouse Motor Cortex

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    Activity in the mouse anterior lateral motor cortex (ALM) instructs directional movements, often seconds before movement initiation. It is unknown whether this preparatory activity is localized to ALM …

  37. Maintenance of persistent activity in a frontal thalamocortical loop

    Publication
    Persistent neural activity maintains information that connects past and future events. Models of persistent activity often invoke reverberations within local cortical circuits, but long-range circuits could also …

  38. Layer 4 fast-spiking interneurons filter thalamocortical signals during active somatosensation

    Publication
    We rely on movement to explore the environment, for example, by palpating an object. In somatosensory cortex, activity related to movement of digits or whiskers is suppressed, which …