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  1. Cell-type-specific population dynamics of diverse reward computations

    Publication
    Computational analysis of cellular activity has developed largely independently of modern transcriptomic cell typology, but integrating these approaches may be essential for full insight into cellular-level mechanisms …

  2. Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex

    Publication
    Recent advances in multi-electrode array technology have made it possible to monitor large neuronal ensembles at cellular resolution in animal models. In humans, however, current approaches restrict …

  3. Cortical preparatory activity indexes learned motor memories

    Publication
    The brain's remarkable ability to learn and execute various motor behaviours harnesses the capacity of neural populations to generate a variety of activity patterns. Here we explore …

  4. Dendritic calcium signals in rhesus macaque motor cortex drive an optical brain-computer interface

    Publication

  5. High-performance brain-to-text communication via handwriting

    Publication
    Brain-computer interfaces (BCIs) can restore communication to people who have lost the ability to move or speak. So far, a major focus of BCI research has been …

  6. Measurement, manipulation and modeling of brain-wide neural population dynamics

    Publication
    Neural recording technologies increasingly enable simultaneous measurement of neural activity from multiple brain areas. To gain insight into distributed neural computations, a commensurate advance in experimental and analytical …

  7. The Neural Representation of Force across Grasp Types in Motor Cortex of Humans with Tetraplegia

    Publication
    Intracortical brain-computer interfaces (iBCIs) have the potential to restore hand grasping and object interaction to individuals with tetraplegia. Optimal grasping and object interaction require simultaneous production of …

  8. Decoding and perturbing decision states in real time

    Publication
    In dynamic environments, subjects often integrate multiple samples of a signal and combine them to reach a categorical judgment1. The process of deliberation can be described by a …

  9. An Open Resource for Non-human Primate Optogenetics

    Publication
    Optogenetics has revolutionized neuroscience in small laboratory animals, but its effect on animal models more closely related to humans, such as non-human primates (NHPs), has been mixed …

  10. Structure in Neural Activity during Observed and Executed Movements Is Shared at the Neural Population Level, Not in Single Neurons

    Publication
    In multiple cortical areas, including the motor cortex, neurons have similar firing rate statistics whether we observe or execute movements. These "congruent" neurons are hypothesized to support action …

  11. A low-power band of neuronal spiking activity dominated by local single units improves the performance of brain-machine interfaces

    Publication
    The large power requirement of current brain-machine interfaces is a major hindrance to their clinical translation. In basic behavioural tasks, the downsampled magnitude of the 300-1 …

  12. Computation Through Neural Population Dynamics

    Publication
    Significant experimental, computational, and theoretical work has identified rich structure within the coordinated activity of interconnected neural populations. An emerging challenge now is to uncover the nature of …

  13. Hand Knob Area of Premotor Cortex Represents the Whole Body in a Compositional Way.

    Publication
    Decades after the motor homunculus was first proposed, it is still unknown how different body parts are intermixed and interrelated in human motor cortical areas at single-neuron …

  14. Causal Role of Motor Preparation during Error-Driven Learning.

    Publication
    Current theories suggest that an error-driven learning process updates trial-by-trial to facilitate motor adaptation. How this process interacts with motor cortical preparatory activity-which current …

  15. Speech-related dorsal motor cortex activity does not interfere with iBCI cursor control.

    Publication
    OBJECTIVE: Speech-related neural modulation was recently reported in 'arm/hand' area of human dorsal motor cortex that is used as a signal source for intracortical brain-computer …

  16. Neural ensemble dynamics in dorsal motor cortex during speech in people with paralysis.

    Publication
    Speaking is a sensorimotor behavior whose neural basis is difficult to study with single neuron resolution due to the scarcity of human intracortical measurements. We used electrode arrays …

  17. Discovering Precise Temporal Patterns in Large-Scale Neural Recordings through Robust and Interpretable Time Warping.

    Publication
    Though the temporal precision of neural computation has been studied intensively, a data-driven determination of this precision remains a fundamental challenge. Reproducible spike patterns may be obscured …

  18. Simultaneous motor preparation and execution in alast-moment reach correction task

    Publication
    Motor preparation typically precedes movement and is thought to determine properties of upcoming movements. However, preparation has mostly been studied in point-to-point delayed reaching tasks. Here …

  19. Accurate Estimation of Neural Population Dynamics without Spike Sorting.

    Publication
    A central goal of systems neuroscience is to relate an organism's neural activity to behavior. Neural population analyses often reduce the data dimensionality to focus on relevant …

  20. Macaque dorsal premotor cortex exhibits decision-related activity only when specific stimulus-response associations are known.

    Publication
    How deliberation on sensory cues and action selection interact in decision-related brain areas is still not well understood. Here, monkeys reached to one of two targets, whose …

  21. Macaque dorsal premotor cortex exhibits decision-related activity only when specific stimulus-response associations are known.

    Publication
    How deliberation on sensory cues and action selection interact in decision-related brain areas is still not well understood. Here, monkeys reached to one of two targets, whose …

  22. Structure and variability of delay activity in premotor cortex.

    Publication
    Voluntary movements are widely considered to be planned before they are executed. Recent studies have hypothesized that neural activity in motor cortex during preparation acts as an 'initial …

  23. Frequency shifts and depth dependence of premotor beta band activity during perceptual decision-making.

    Publication
    … premotor cortex of monkeys performing a decision-making task. Our key finding is that BBA is not a monolithic signal. Instead, BBA consists of at least two …

  24. Cortical control of a tablet computer by people with paralysis.

    Publication
    General-purpose computers have become ubiquitous and important for everyday life, but they are difficult for people with paralysis to use. Specialized software and personalized input devices can …

  25. Brain-machine interface cursor position only weakly affects monkey and human motor cortical activity in the absence of arm movements.

    Publication
    Brain-machine interfaces (BMIs) that decode movement intentions should ignore neural modulation sources distinct from the intended command. However, neurophysiology and control theory suggest that motor cortex reflects …

  26. Unsupervised Discovery of Demixed, Low-Dimensional Neural Dynamics across Multiple Timescales through Tensor Component Analysis

    Publication
    Perceptions, thoughts, and actions unfold over millisecond timescales, while learned behaviors can require many days to mature. While recent experimental advances enable large-scale and long-term neural …

  27. Development of an optogenetic toolkit for neural circuit dissection in squirrel monkeys.

    Publication
    Optogenetic tools have opened a rich experimental landscape for understanding neural function and disease. Here, we present the first validation of eight optogenetic constructs driven by recombinant adeno …

  28. Stable long-term BCI-enabled communication in ALS and locked-in syndrome using LFP signals.

    Publication
    Restoring communication for people with locked-in syndrome remains a challenging clinical problem without a reliable solution. Recent studies have shown that people with paralysis can use brain …

  29. Neural Population Dynamics Underlying Motor Learning Transfer.

    Publication
    Covert motor learning can sometimes transfer to overt behavior. We investigated the neural mechanism underlying transfer by constructing a two-context paradigm. Subjects performed cursor movements either overtly …

  30. ERAASR: An algorithm for removing electrical stimulation artifacts from multielectrode array recordings.

    Publication
    Electrical stimulation is a widely used and effective tool in systems neuroscience, neural prosthetics, and clinical neurostimulation. However, electrical artifacts evoked by stimulation prevent the detection of spiking …

  31. Augmenting intracortical brain-machine interface with neurally driven error detectors.

    Publication
    OBJECTIVE: Making mistakes is inevitable, but identifying them allows us to correct or adapt our behavior to improve future performance. Current brain-machine interfaces (BMIs) make errors that …

  32. Laminar differences in decision-related neural activity in dorsal premotor cortex.

    Publication
    Dorsal premotor cortex is implicated in somatomotor decisions. However, we do not understand the temporal patterns and laminar organization of decision-related firing rates in dorsal premotor cortex …

  33. Motor Cortical Visuomotor Feedback Activity Is Initially Isolated from Downstream Targets in Output-Null Neural State Space Dimensions

    Publication
    Neural circuits must transform new inputs into outputs without prematurely affecting downstream circuits while still maintaining other ongoing communication with these targets. We investigated how this isolation is …

  34. Trial-by-Trial Motor Cortical Correlates of a Rapidly Adapting Visuomotor Internal Model

    Publication
    … after specific movements and errors. Furthermore, the ability to estimate the internal model before movement could improve motor neural prostheses being developed for people with paralysis.