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  1. Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes

    Publication

  2. Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes

    Publication

  3. A microengineered Brain-Chip to model neuroinflammation in humans

    Publication
    Species differences in brain and blood-brain barrier (BBB) biology hamper the translation of findings from animal models to humans, impeding the development of therapeutics for brain diseases …

  4. FOS licenses early events in stem cell activation driving skeletal muscle regeneration

    Publication
    Muscle satellite cells (SCs) are a quiescent (non-proliferative) stem cell population in uninjured skeletal muscle. Although SCs have been investigated for nearly 60 years, the molecular drivers …

  5. Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption

    Publication
    Parkinson's disease and related synucleinopathies are characterized by the abnormal accumulation of alpha-synuclein aggregates, loss of dopaminergic neurons, and gliosis of the substantia nigra. Although clinical …

  6. Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption

    Publication
    Parkinson's disease and related synucleinopathies are characterized by the abnormal accumulation of alpha-synuclein aggregates, loss of dopaminergic neurons, and gliosis of the substantia nigra. Although clinical …

  7. GDF11 expressed in the adult brain negatively regulates hippocampal neurogenesis

    Publication
    Growth differentiation factor 11 (GDF11) is a transforming factor-β superfamily member that functions as a negative regulator of neurogenesis during embryonic development. However, when recombinant GDF11 (rGDF11 …

  8. Synthetic modified Fezf2 mRNA (modRNA) with concurrent small molecule SIRT1 inhibition enhances refinement of cortical subcerebral/corticospinal neuron identity from mouse embryonic stem cells

    Publication
    During late embryonic development of the cerebral cortex, the major class of cortical output neurons termed subcerebral projection neurons (SCPN; including the predominant population of corticospinal neurons, CSN …

  9. Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging

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  10. Accelerating diagnosis of Parkinson's disease through risk prediction

    Publication

  11. Accelerating diagnosis of Parkinson's disease through risk prediction

    Publication
    Background: Characterization of prediagnostic Parkinson's Disease (PD) and early prediction of subsequent development are critical for preventive interventions, risk stratification and understanding of disease pathology. This study …

  12. Single-cell transcriptomic profiling of the aging mouse brain

    Publication
    The mammalian brain is complex, with multiple cell types performing a variety of diverse functions, but exactly how each cell type is affected in aging remains largely unknown …