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  1. All-optical physiology resolves a synaptic basis for behavioral timescale plasticity

    Publication

  2. Neural ensembles in navigation: From single cells to population codes

    Publication

  3. Neural circuit dynamics of drug-context associative learning in the mouse hippocampus

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  4. From Rats to Humans: how novel behavioral paradigms and reinforcement learning can bridge the gap in translation

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  5. A unified theory for the computational and mechanistic origins of grid cells

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    The discovery of entorhinal grid cells has generated considerable interest in how and why hexagonal firing fields might emerge in a generic manner from neural circuits, and what …

  6. Distance-tuned neurons drive specialized path integration calculations in medial entorhinal cortex

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    During navigation, animals estimate their position using path integration and landmarks, engaging many brain areas. Whether these areas follow specialized or universal cue integration principles remains incompletely understood …

  7. The grid code for ordered experience

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    Entorhinal cortical grid cells fire in a periodic pattern that tiles space, which is suggestive of a spatial coordinate system. However, irregularities in the grid pattern as well …

  8. Dynamic and reversible remapping of network representations in an unchanging environment

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    Neurons in the medial entorhinal cortex alter their firing properties in response to environmental changes. This flexibility in neural coding is hypothesized to support navigation and memory by …

  9. Navigating for reward

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    An organism's survival can depend on its ability to recall and navigate to spatial locations associated with rewards, such as food or a home. Accumulating research has …

  10. Spatial memory: Place cell activity is causally related to behavior

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    A recent study using new holographic optogenetic stimulation technology has provided direct evidence that hippocampal place cell activity is sufficient to drive memory and navigation-related behaviors.

  11. Experience-dependent contextual codes in the hippocampus

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    The hippocampus contains neural representations capable of supporting declarative memory. Hippocampal place cells are one such representation, firing in one or few locations in a given environment. Between …

  12. Topography in the Bursting Dynamics of Entorhinal Neurons

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    Medial entorhinal cortex contains neural substrates for representing space. These substrates include grid cells that fire in repeating locations and increase in scale progressively along the dorsal-to …

  13. Mouse entorhinal cortex encodes a diverse repertoire of self-motion signals

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    Neural circuits generate representations of the external world from multiple information streams. The navigation system provides an exceptional lens through which we may gain insights about how such …

  14. Multiple head direction signals within entorhinal cortex: origin and function

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    Sensory systems show hierarchical computation, starting from primary sensory receptors, with information transformed into multimodal representations as they move through subcortical and cortical brain regions. Here, we discuss …

  15. Topography in the Bursting Dynamics of Entorhinal Neurons.

    Publication
    Medial entorhinal cortex contains neural substrates for representing space. These substrates include grid cells that fire in repeating locations and increase in scale progressively along the dorsal-to …

  16. Entorhinal velocity signals reflect environmental geometry

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    The entorhinal cortex contains neurons that represent self-location, including grid cells that fire in periodic locations and velocity signals that encode running speed and head direction. Although …

  17. Remembered reward locations restructure entorhinal spatial maps.

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    Ethologically relevant navigational strategies often incorporate remembered reward locations. Although neurons in the medial entorhinal cortex provide a maplike representation of the external spatial world, whether this map …

  18. Emergent elasticity in the neural code for space

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    Upon encountering a novel environment, an animal must construct a consistent environmental map, as well as an internal estimate of its position within that map, by combining information …

  19. Self-motion processing in visual and entorhinal cortices: Inputs, integration, and implications for position coding.

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    The sensory signals generated by self-motion are complex and multimodal, but the ability to integrate these signals into a unified self-motion percept to guide navigation is …

  20. Principles governing the integration of landmark and self-motion cues in entorhinal cortical codes for navigation.

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    To guide navigation, the nervous system integrates multisensory self-motion and landmark information. We dissected how these inputs generate spatial representations by recording entorhinal grid, border and speed …

  21. Grid scale drives the scale and long-term stability of place maps

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    Medial entorhinal cortex (MEC) grid cells fire at regular spatial intervals and project to the hippocampus, where place cells are active in spatially restricted locations. One feature of …

  22. Heterogeneity in hippocampal place coding.

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    The discovery of place cells provided fundamental insight into the neural basis by which the hippocampus encodes spatial memories and supports navigation and prompted the development of computational …

  23. Grid scale drives the scale and long-term stability of place maps.

    Publication
    Medial entorhinal cortex (MEC) grid cells fire at regular spatial intervals and project to the hippocampus, where place cells are active in spatially restricted locations. One feature of …

  24. Cell types for our sense of location: where we are and where we are going.

    Publication
    Technological advances in profiling cells along genetic, anatomical and physiological axes have fomented interest in identifying all neuronal cell types. This goal nears completion in specialized circuits such …

  25. A Multiplexed, Heterogeneous, and Adaptive Code for Navigation in Medial Entorhinal Cortex.

    Publication