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  1. Residual dynamics resolves recurrent contributions to neural computation

    Publication

  2. Learning shapes cortical dynamics to enhance integration of relevant sensory input

    Publication
    Adaptive sensory behavior is thought to depend on processing in recurrent cortical circuits, but how dynamics in these circuits shapes the integration and transmission of sensory information is …

  3. Learning and attention increase visual response selectivity through distinct mechanisms

    Publication
    Selectivity of cortical neurons for sensory stimuli can increase across days as animals learn their behavioral relevance and across seconds when animals switch attention. While both phenomena occur …

  4. Dynamics on the manifold: Identifying computational dynamical activity from neural population recordings

    Publication
    The question of how the collective activity of neural populations gives rise to complex behaviour is fundamental to neuroscience. At the core of this question lie considerations about …

  5. Dendritic calcium signals in rhesus macaque motor cortex drive an optical brain-computer interface

    Publication

  6. Sustained Activation of PV+ Interneurons in Core Auditory Cortex Enables Robust Divisive Gain Control for Complex and Naturalistic Stimuli

    Publication
    Sensory cortices must flexibly adapt their operations to internal states and external requirements. Sustained modulation of activity levels in different inhibitory interneuron populations may provide network-level mechanisms …

  7. Movement initiation and grasp representation in premotor and primary motor cortex mirror neurons

    Publication
    Pyramidal tract neurons (PTNs) within macaque rostral ventral premotor cortex (F5) and (M1) provide direct input to spinal circuitry and are critical for skilled movement control. Contrary to …

  8. A Head-Mounted Camera System Integrates Detailed Behavioral Monitoring with Multichannel Electrophysiology in Freely Moving Mice.

    Publication
    Breakthroughs in understanding the neural basis of natural behavior require neural recording and intervention to be paired with high-fidelity multimodal behavioral monitoring. An extensive genetic toolkit for …

  9. Distinct learning-induced changes in stimulus selectivity and interactions of GABAergic interneuron classes in visual cortex.

    Publication
    How learning enhances neural representations for behaviorally relevant stimuli via activity changes of cortical cell types remains unclear. We simultaneously imaged responses of pyramidal cells (PYR) along with …

  10. The Impact of Anesthetic State on Spike-Sorting Success in the Cortex: A Comparison of Ketamine and Urethane Anesthesia.

    Publication
    Spike sorting is an essential first step in most analyses of extracellular in vivo electrophysiological recordings. Here we show that spike-sorting success depends critically on characteristics of …