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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

  • All News
  • Research News
  • Funding Announcements
  • Newsletter Sign Up
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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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  • Presidential Lectures
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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. A set of hub neurons and non-local connectivity features support global brain dynamics in C. elegans

    Publication
    The wiring architecture of neuronal networks is assumed to be a strong determinant of their dynamical computations. An ongoing effort in neuroscience is therefore to generate comprehensive synapse …
  2. Methods for analyzing neuronal structure and activity in Caenorhabditis elegans

    Publication
  3. Unsupervised learning of control signals and their encodings in Caenorhabditis elegans whole-brain recordings

    Publication
    A major goal of computational neuroscience is to understand the relationship between synapse-level structure and network-level functionality. Caenorhabditis elegans is a model organism to probe this …
  4. Brain-wide representations of ongoing behavior: a universal principle?

    Publication
    Recent neuronal activity recordings of unprecedented breadth and depth in worms, flies, and mice have uncovered a surprising common feature: brain-wide behavior-related signals. These signals pervade …
  5. Nested Neuronal Dynamics Orchestrate a Behavioral Hierarchy across Timescales

    Publication
    Classical and modern ethological studies suggest that animal behavior is organized hierarchically across timescales, such that longer-timescale behaviors are composed of specific shorter-timescale actions. Despite progress …
  6. Sensorimotor integration in Caenorhabditis elegans: a reappraisal towards dynamic and distributed computations.

    Publication
    The nematode Caenorhabditis elegans is a tractable model system to study locomotion, sensory navigation and decision-making. In its natural habitat, it is thought to navigate complex multisensory …
  7. A global brain state underlies C. elegans sleep behavior

    Publication
    How the brain effectively switches between and maintains global states, such as sleep and wakefulness, is not yet understood. We used brainwide functional imaging at single-cell resolution …

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