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  1. The centrality of population-level factors to network computation is demonstrated by a versatile approach for training spiking networks

    Publication

  2. Flexible neural control of motor units

    Publication
    Voluntary movement requires communication from cortex to the spinal cord, where a dedicated pool of motor units (MUs) activates each muscle. The canonical description of MU function rests …

  3. Motor cortex activity across movement speeds is predicted by network-level strategies for generating muscle activity

    Publication
    Learned movements can be skillfully performed at different paces. What neural strategies produce this flexibility? Can they be predicted and understood by network modeling? We trained monkeys to …

  4. Independent generation of sequence elements by motor cortex

    Publication
    Rapid execution of motor sequences is believed to depend on fusing movement elements into cohesive units that are executed holistically. We sought to determine the contribution of primary …

  5. Neural Trajectories in the Supplementary Motor Area and Motor Cortex Exhibit Distinct Geometries, Compatible with Different Classes of Computation.

    Publication
    The supplementary motor area (SMA) is believed to contribute to higher order aspects of motor control. We considered a key higher order role: tracking progress throughout an action …

  6. Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response

    Publication
    Motor cortex (M1) has lateralized outputs, yet neurons can be active during movements of either arm. What is the nature and role of activity across the two hemispheres …

  7. Conservation of preparatory neural events in monkey motor cortex regardless of how movement is initiated

    Publication
    A time-consuming preparatory stage is hypothesized to precede voluntary movement. A putative neural substrate of motor preparation occurs when a delay separates instruction and execution cues. When …

  8. Different population dynamics in the supplementary motor area and motor cortex during reaching.

    Publication
    Neural populations perform computations through their collective activity. Different computations likely require different population-level dynamics. We leverage this assumption to examine neural responses recorded from the supplementary …

  9. Motor Cortex Embeds Muscle-like Commands in an Untangled Population Response

    Publication
    Primate motor cortex projects to spinal interneurons and motoneurons, suggesting that motor cortex activity may be dominated by muscle-like commands. Observations during reaching lend support to this …

  10. Behaviorally Selective Engagement of Short-Latency Effector Pathways by Motor Cortex

    Publication
    Blocking motor cortical output with lesions or pharmacological inactivation has identified movements that require motor cortex. Yet, when and how motor cortex influences muscle activity during movement execution …

  11. Reorganization between preparatory and movement population responses in motor cortex

    Publication
    Neural populations can change the computation they perform on very short timescales. Although such flexibility is common, the underlying computational strategies at the population level remain unknown. To …