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  1. Behaviorally relevant decision coding in primary somatosensory cortex neurons

    Publication
    Primary sensory cortex is thought to process incoming sensory information, while decision variables important for driving behavior are assumed to arise downstream in the processing hierarchy. Here, we …

  2. All-optical interrogation of neural circuits in behaving mice

    Publication
    Recent advances combining two-photon calcium imaging and two-photon optogenetics with computer-generated holography now allow us to read and write the activity of large populations of …

  3. Reward signals in the cerebellum: Origins, targets, and functional implications

    Publication
    The cerebellum has long been proposed to play a role in cognitive function, although this has remained controversial. This idea has received renewed support with the recent discovery …

  4. Active dendrites enable strong but sparse inputs to determine orientation selectivity

    Publication
    The dendrites of neocortical pyramidal neurons are excitable. However, it is unknown how synaptic inputs engage nonlinear dendritic mechanisms during sensory processing in vivo, and how they in …

  5. Standardized and reproducible measurement of decision-making in mice

    Publication
    Progress in science requires standardized assays whose results can be readily shared, compared, and reproduced across laboratories. Reproducibility, however, has been a concern in neuroscience, particularly for measurements …

  6. Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings

    Publication
    Measuring the dynamics of neural processing across time scales requires following the spiking of thousands of individual neurons over milliseconds and months. To address this need, we introduce …

  7. Purkinje Cell Activity Determines the Timing of Sensory-Evoked Motor Initiation

    Publication
    Cerebellar neurons can signal sensory and motor events, but their role in active sensorimotor processing remains unclear. We record and manipulate Purkinje cell activity during a task that …

  8. Targeted Activation of Hippocampal Place Cells Drives Memory-Guided Spatial Behavior

    Publication
    The hippocampus is crucial for spatial navigation and episodic memory formation. Hippocampal place cells exhibit spatially selective activity within an environment and have been proposed to form the …

  9. How many neurons are sufficient for perception of cortical activity?

    Publication
    Many theories of brain function propose that activity in sparse subsets of neurons underlies perception and action. To place a lower bound on the amount of neural activity …

  10. Microcircuit Rules Governing Impact of Single Interneurons on Purkinje Cell Output In Vivo.

    Publication
    The functional impact of single interneurons on neuronal output in vivo and how interneurons are recruited by physiological activity patterns remain poorly understood. In the cerebellar cortex, molecular …

  11. Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies.

    Publication
    Parvalbumin-expressing (PV+) GABAergic interneurons mediate feedforward and feedback inhibition and have a key role in gamma oscillations and information processing. The importance of fast synaptic recruitment and …

  12. Predictive and reactive reward signals conveyed by climbing fiber inputs to cerebellar Purkinje cells.

    Publication
    There is increasing evidence for a cerebellar contribution to cognitive processing, but the specific input pathways conveying this information remain unclear. We probed the role of climbing fiber …

  13. Closed-loop all-optical interrogation of neural circuits in vivo.

    Publication
    Understanding the causal relationship between neural activity and behavior requires the ability to perform rapid and targeted interventions in ongoing activity. Here we describe a closed-loop all …

  14. Fully integrated silicon probes for high-density recording of neural activity.

    Publication
    Sensory, motor and cognitive operations involve the coordinated action of large neuronal populations across multiple brain regions in both superficial and deep structures. Existing extracellular probes record neural …

  15. Aberrant Cortical Activity in Multiple GCaMP6-Expressing Transgenic Mouse Lines.

    Publication
    Transgenic mouse lines are invaluable tools for neuroscience but, as with any technique, care must be taken to ensure that the tool itself does not unduly affect the …