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  1. Time-resolved correlation of distributed brain activity tracks E-I balance and accounts for diverse scale-free phenomena

    Publication

  2. Fast and sensitive GCaMP calcium indicators for imaging neural populations

    Publication

  3. Dimensionality reduction of calcium-imaged neuronal population activity

    Publication

  4. A brainstem integrator for self-location memory and positional homeostasis in zebrafish

    Publication

  5. Voltage imaging identifies spinal circuits that modulate locomotor adaptation in zebrafish

    Publication
    Motor systems must continuously adapt their output to maintain a desired trajectory. While the spinal circuits underlying rhythmic locomotion are well described, little is known about how the …

  6. Brain-wide, scale-wide physiology underlying behavioral flexibility in zebrafish

    Publication
    The brain is tasked with choosing actions that maximize an animal's chances of survival and reproduction. These choices must be flexible and informed by the current state …

  7. Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator

    Publication
    Methods for one-photon fluorescent imaging of calcium dynamics can capture the activity of hundreds of neurons across large fields of view at a low equipment complexity and …

  8. A bidirectional network for appetite control in larval zebrafish.

    Publication
    Medial and lateral hypothalamic loci are known to suppress and enhance appetite, respectively, but the dynamics and functional significance of their interaction have yet to be explored. Here …

  9. Bright and photostable chemigenetic indicators for extended in vivo voltage imaging.

    Publication
    Genetically encoded voltage indicators (GEVIs) enable monitoring of neuronal activity at high spatial and temporal resolution. However, the utility of existing GEVIs has been limited by the brightness …

  10. A genetically encoded fluorescent sensor for in vivo imaging of GABA.

    Publication
    Current techniques for monitoring GABA (γ-aminobutyric acid), the primary inhibitory neurotransmitter in vertebrates, cannot follow transients in intact neural circuits. To develop a GABA sensor, we applied …

  11. Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful Behavior

    Publication
    When a behavior repeatedly fails to achieve its goal, animals often give up and become passive, which can be strategic for preserving energy or regrouping between attempts. It …

  12. Brain-wide circuit interrogation at the cellular level guided by online analysis of neuronal function.

    Publication
    Whole-brain imaging allows for comprehensive functional mapping of distributed neural pathways, but neuronal perturbation experiments are usually limited to targeting predefined regions or genetically identifiable cell types …

  13. Brain-wide Organization of Neuronal Activity and Convergent Sensorimotor Transformations in Larval Zebrafish.

    Publication
    Simultaneous recordings of large populations of neurons in behaving animals allow detailed observation of high-dimensional, complex brain activity. However, experimental approaches often focus on singular behavioral paradigms …

  14. Integrative whole-brain neuroscience in larval zebrafish.

    Publication
    Due to their small size and transparency, zebrafish larvae are amenable to a range of fluorescence microscopy techniques. With the development of sensitive genetically encoded calcium indicators, this …

  15. Multi-scale approaches for high-speed imaging and analysis of large neural populations.

    Publication
    Progress in modern neuroscience critically depends on our ability to observe the activity of large neuronal populations with cellular spatial and high temporal resolution. However, two bottlenecks constrain …

  16. The Serotonergic System Tracks the Outcomes of Actions to Mediate Short-Term Motor Learning

    Publication
    To execute accurate movements, animals must continuously adapt their behavior to changes in their bodies and environments. Animals can learn changes in the relationship between their locomotor commands …