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  1. Thalamus-driven functional populations in frontal cortex support decision-making

    Publication
    Neurons in frontal cortex exhibit diverse selectivity representing sensory, motor and cognitive variables during decision-making. The neural circuit basis for this complex selectivity remains unclear. We examined …

  2. A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement

    Publication
    Motor behaviors are often planned long before execution but only released after specific sensory events. Planning and execution are each associated with distinct patterns of motor cortex activity …

  3. Accurate Localization of Linear Probe Electrode Arrays across Multiple Brains

    Publication
    Recently developed probes for extracellular electrophysiological recordings have large numbers of electrodes on long linear shanks. Linear electrode arrays, such as Neuropixels probes, have hundreds of recording electrodes …

  4. Modularity and robustness of frontal cortical networks

    Publication

  5. Attractor dynamics gate cortical information flow during decision-making

    Publication
    Decisions are held in memory until enacted, which makes them potentially vulnerable to distracting sensory input. Gating of information flow from sensory to motor areas could protect memory …

  6. Cortico-cerebellar interactions during goal-directed behavior

    Publication
    Preparatory activity is observed across multiple interconnected brain regions before goal-directed movement. Preparatory activity reflects discrete activity states representing specific future actions. It is unclear how this …

  7. Mechanisms underlying the response of mouse cortical networks to optogenetic manipulation.

    Publication
    GABAergic interneurons can be subdivided into three subclasses: parvalbumin positive (PV), somatostatin positive (SOM) and serotonin positive neurons. With principal cells (PCs) they form complex networks. We examine …

  8. Spatiotemporal constraints on optogenetic inactivation in cortical circuits.

    Publication
    Optogenetics allows manipulations of genetically and spatially defined neuronal populations with excellent temporal control. However, neurons are coupled with other neurons over multiple length scales, and the effects …

  9. An orderly single-trial organization of population dynamics in premotor cortex predicts behavioral variability

    Publication
    Animals are not simple input-output machines. Their responses to even very similar stimuli are variable. A key, long-standing question in neuroscience is to understand the neural …

  10. A cortico-cerebellar loop for motor planning

    Publication
    Persistent and ramping neural activity in the frontal cortex anticipates specific movements. Preparatory activity is distributed across several brain regions, but it is unclear which brain areas are …

  11. Neural mechanisms of movement planning: motor cortex and beyond.

    Publication
    Neurons in motor cortex and connected brain regions fire in anticipation of specific movements, long before movement occurs. This neural activity reflects internal processes by which the brain …