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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

  • All News
  • Research News
  • Funding Announcements
  • Newsletter Sign Up
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  • Media Relations

We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Metacognitive computations for information search: Confidence in control

    Publication
  2. Formalising social representation to explain psychiatric symptoms

    Publication
  3. The role of the lateral orbitofrontal cortex in creating cognitive maps

    Publication
  4. Freezing revisited: coordinated autonomic and central optimization of threat coping

    Publication
    Animals have sophisticated mechanisms for coping with danger. Freezing is a unique state that, upon threat detection, allows evidence to be gathered, response possibilities to be previsioned and …
  5. Neurofeedback through the lens of reinforcement learning

    Publication
    Despite decades of experimental and clinical practice, the neuropsychological mechanisms underlying neurofeedback (NF) training remain obscure. NF is a unique form of reinforcement learning (RL) task, during which …
  6. Spatial preferences account for inter-animal variability during the continual learning of a dynamic cognitive task

    Publication
    Understanding the complexities of behavior is necessary to interpret neurophysiological data and establish animal models of neuropsychiatric disease. This understanding requires knowledge of the underlying information-processing structure …
  7. The Anterior Cingulate Cortex Predicts Future States to Mediate Model-Based Action Selection

    Publication
    Behavioral control is not unitary. It comprises parallel systems, model based and model free, that respectively generate flexible and habitual behaviors. Model-based decisions use predictions of the …
  8. Memory Alone Does Not Account for the Way Rats Learn a Simple Spatial Alternation Task

    Publication
    Animal behavior provides context for understanding disease models and physiology. However, that behavior is often characterized subjectively, creating opportunity for misinterpretation and misunderstanding. For example, spatial alternation tasks …
  9. Combined model-free and model-sensitive reinforcement learning in non-human primates

    Publication
    Contemporary reinforcement learning (RL) theory suggests that potential choices can be evaluated by strategies that may or may not be sensitive to the computational structure of tasks. A …
  10. Representation, abstraction, and simple-minded sophisticates

    Publication
    Bayesian decision theory provides a simple formal elucidation of some of the ways that representation and representational abstraction are involved with, and exploit, both prediction and its rather …
  11. Space, Time, and Fear: Survival Computations along Defensive Circuits.

    Publication
    Naturalistic observations show that decisions to avoid or escape predators occur at different spatiotemporal scales and that they are supported by different computations and neural circuits. At their …
  12. A computational account of threat-related attentional bias.

    Publication
    isual selective attention acts as a filter on perceptual information, facilitating learning and inference about important events in an agent's environment. A role for visual attention in …
  13. Backtracking during navigation is correlated with enhanced anterior cingulate activity and suppression of alpha oscillations and the 'default-mode' network.

    Publication
    Successful navigation can require realizing the current path choice was a mistake and the best strategy is to retreat along the recent path: 'back-track'. Despite the wealth …
  14. Learning to use past evidence in a sophisticated world model.

    Publication
    Humans and other animals are able to discover underlying statistical structure in their environments and exploit it to achieve efficient and effective performance. However, such structure is often …
  15. Forget-me-some: General versus special purpose models in a hierarchical probabilistic task.

    Publication
    Humans build models of their environments and act according to what they have learnt. In simple experimental environments, such model-based behaviour is often well accounted for as …
  16. Pavlovian-instrumental interactions in active avoidance: The bark of neutral trials.

    Publication
    In active avoidance tasks, subjects have to learn to execute particular actions in order to avoid an aversive stimulus, such as a shock. Such paradigms pose a number …
  17. An effect of serotonergic stimulation on learning rates for rewards apparent after long intertrial intervals.

    Publication
    Serotonin has widespread, but computationally obscure, modulatory effects on learning and cognition. Here, we studied the impact of optogenetic stimulation of dorsal raphe serotonin neurons in mice performing …
  18. Foraging for foundations in decision neuroscience: insights from ethology.

    Publication
    Modern decision neuroscience offers a powerful and broad account of human behaviour using computational techniques that link psychological and neuroscientific approaches to the ways that individuals can generate …
  19. Interrupting behaviour: Minimizing decision costs via temporal commitment and low-level interrupts.

    Publication
    Ideal decision-makers should constantly assess all sources of information about opportunities and threats, and be able to redetermine their choices promptly in the face of change. However …

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