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  1. Polarization of the Drosophila oocyte by active cortical exchange

    Publication
    Anterior-posterior polarization in the Drosophila oocyte requires posterior localization of oskar mRNA. oskar mRNA is produced in the anteriorly situated nurse cells, moved into the oocyte, and …

  2. Traveling Waves Enhance Transport during Cytoplasmic Streaming in Drosophila Oogenesis

    Publication
    Cytoplasmic streaming is believed crucial to large developing cells, such as oocytes, where flow provides a much faster route to transport and mixing of cellular components than molecular …

  3. Cell size reduction scales spindle elongation but not chromosome segregation in C. elegans

    Publication
    How embryos adapt their internal cellular machinery to reductions in cell size during development remains a fundamental question in cell biology. Here, we use high-resolution lattice light …

  4. Geometric optics organizes organelle interactions and positioning

    Publication
    Microtubule asters are central to positioning organelles and organizing intracellular architectures. We show that the multi-stage choreography of microtubule asters which positions pronuclei during the first cell …

  5. Cell size reduction drives spindle scaling but not chromosome segregation in C. elegans

    Publication
    How embryos adapt their internal cellular machinery to reductions in cell size during development remains a fundamental question in cell biology1–11. Here, we use high-resolution lattice …

  6. Cell size reduction scales spindle elongation but not chromosome segregation in C. elegans

    Publication
    How embryos adapt their internal cellular machinery to reductions in cell size during development remains a fundamental question in cell biology1–11. Here, we use high-resolution lattice …

  7. The Wnt co-receptor Arrow-LRP5/6 is required for Planar Cell Polarity establishment in Drosophila

    Publication
    Wnt-signaling, via β-catenin or the planar cell polarity (PCP) branch, is crucial for development, tissue homeostasis, and linked to many diseases. LRP5/6, arrow (arr) in …

  8. Geometric Effects in Large Scale Intracellular Flows

    Publication
    This work probes the role of cell geometry in orienting self-organized fluid flows in the late-stage Drosophila oocyte. Recent theoretical work has shown that a model …

  9. Geometric model for dynamics of motor-driven centrosomal asters

    Publication
    The centrosomal aster is a mobile and adaptable cellular organelle that exerts and transmits forces necessary for tasks such as nuclear migration and spindle positioning. Recent experimental and …

  10. Mechanics and morphology of proliferating cell collectives with self-inhibiting growth

    Publication
    We study the dynamics of proliferating cell collectives whose microscopic constituents’ growth is inhibited by macroscopic growth-induced stress. Discrete particle simulations of a growing collective show the …

  11. Mechanics of spindle orientation in human mitotic cells is determined by pulling forces on astral microtubules and clustering of cortical dynein

    Publication
    The forces that orient the spindle in human cells remain poorly understood due to a lack of direct mechanical measurements in mammalian systems. We use magnetic tweezers to …

  12. Self-organized intracellular twisters

    Publication
    Life in complex systems, such as cities and organisms, comes to a standstill when global coordination of mass, energy and information flows is disrupted. Global coordination is no …

  13. Clustering of cortical dynein regulates the mechanics of spindle orientation in human mitotic cells

    Publication
    The forces which orient the spindle in human cells remain poorly understood due to a lack of direct mechanical measurements in mammalian systems. We use magnetic tweezers to …

  14. Spindle dynamics and orientation depends in forge generators configuration

    Publication
    During cell division, the mitotic spindle forms inside cells and segregates chromosomes. The spindle's position sets the division plane, which is essential for proper growth and development …

  15. Stoichiometric interactions explain spindle dynamics and scaling across 100 million years of nematode evolution

    Publication
    The spindle shows remarkable diversity, and changes in an integrated fashion, as cells vary over evolution. Here, we provide a mechanistic explanation for variations in the first mitotic …

  16. Use of imaging software for assessment of the associations among zona pellucida thickness variation, assisted hatching, and implantation of day 3 embryos

    Publication
    PURPOSE: The aim of this study was to determine if zona pellucida thickness variation (ZPTV) is associated with implantation and if this relationship changes with use of assisted …