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  1. Individual bitter-sensing neurons in Drosophila exhibit both ON and OFF responses that influence synaptic plasticity

    Publication
    The brain generates internal representations that translate sensory stimuli into appropriate behavior. In the taste system, different tastes activate distinct populations of sensory neurons. We investigated the temporal …

  2. Olfactory landmarks and path integration converge to form a cognitive spatial map

    Publication
    The convergence of internal path integration and external sensory landmarks generates a cognitive spatial map in the hippocampus. We studied how localized odor cues are recognized as landmarks …

  3. Evolving the olfactory system with machine learning

    Publication
    The convergent evolution of the fly and mouse olfactory system led us to ask whether the anatomic connectivity and functional logic of olfactory circuits would evolve in artificial …

  4. Representational drift in primary olfactory cortex

    Publication

  5. Transient and Persistent Representations of Odor Value in Prefrontal Cortex

    Publication
    The representation of odor in olfactory cortex (piriform) is distributive and unstructured and can only be afforded behavioral significance upon learning. We performed 2-photon imaging to examine …

  6. Context-Dependent Decision Making in a Premotor Circuit.

    Publication
    Cognitive capacities afford contingent associations between sensory information and behavioral responses. We studied this problem using an olfactory delayed match to sample task whereby a sample odor specifies …

  7. A virtual burrow assay for head-fixed mice measures habituation, discrimination, exploration and avoidance without training.

    Publication
    We have designed an assay that measures approach and avoidance behaviors in head-fixed mice at millisecond timescale, is compatible with standard electrophysiological and optical methods for measuring …

  8. Odor Perception on the Two Sides of the Brain: Consistency Despite Randomness

    Publication
    Neurons in piriform cortex receive input from a random collection of glomeruli, resulting in odor representations that lack the stereotypic organization of the olfactory bulb. We have performed …

  9. Representations of Novelty and Familiarity in a Mushroom Body Compartment

    Publication
    Animals exhibit a behavioral response to novel sensory stimuli about which they have no prior knowledge. We have examined the neural and behavioral correlates of novelty and familiarity …

  10. Optimal Degrees of Synaptic Connectivity

    Publication
    Synaptic connectivity varies widely across neuronal types. Cerebellar granule cells receive five orders of magnitude fewer inputs than the Purkinje cells they innervate, and cerebellum-like circuits, including …