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  1. Blood-to-brain communication in aging and rejuvenation

    Publication

  2. Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function

    Publication

  3. Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits

    Publication
    Parvalbumin-positive (PV+) interneurons play a critical role in maintaining circuit rhythm in the brain, and their reduction is implicated in autism spectrum disorders. Animal studies demonstrate that …

  4. Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions

    Publication

  5. MHC class I H2-Kb negatively regulates neural progenitor cell proliferation by inhibiting FGFR signaling

    Publication

  6. Dampening the Power of the Brain-When Aging Meets Cognition

    Publication

  7. Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation

    Publication
    Increased neural stem cell (NSC) quiescence is a major determinant of age-related regenerative decline in the adult hippocampus. However, a coextensive model has been proposed in which …

  8. The aged hematopoietic system promotes hippocampal-dependent cognitive decline

    Publication
    The aged systemic milieu promotes cellular and cognitive impairments in the hippocampus. Here, we report that aging of the hematopoietic system directly contributes to the pro-aging effects …

  9. Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age

    Publication
    Adipose tissue eosinophils (ATEs) are important in the control of obesity-associated inflammation and metabolic disease. However, the way in which ageing impacts the regulatory role of ATEs …

  10. Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain

    Publication
    Reversing brain aging may be possible through systemic interventions such as exercise. We found that administration of circulating blood factors in plasma from exercised aged mice transferred the …