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Bringing people and ideas together to fund, conduct, and share transformative science.

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Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Topology and Complexity

November 19, 2014

Results

  1. Semantic Search for 100M+ Galaxy Images Using AI-generated Captions

    Publication
    Finding scientifically interesting phenomena through slow, manual labeling campaigns severely limits our ability to explore the billions of galaxy images produced by telescopes. In this work, we develop …
  2. MIMIC: A Generative Multimodal Foundation Model for Biomolecules

    Publication
    We introduce MIMIC a generative multimodal foundation model trained across biomolecular sequences 3D structures and functional assays. MIMIC performs unified representation learning and conditional generation across nucleic acids …
  3. Predicting partially observable dynamical systems via diffusion models with a multiscale inference scheme

    Publication
    Conditional diffusion models provide a natural framework for probabilistic prediction of dynamical systems and have been successfully applied to fluid dynamics and weather prediction. However, in many settings …
  4. Walrus: A Cross-Domain Foundation Model for Continuum Dynamics

    Publication
    Foundation models have transformed machine learning for language and vision, but achieving comparable impact in physical simulation remains a challenge. Data heterogeneity and unstable long-term dynamics inhibit …
  5. Walrus: A Cross-Domain Foundation Model for Continuum Dynamics

    Publication
    Foundation models have transformed machine learning for language and vision, but achieving comparable impact in physical simulation remains a challenge. Data heterogeneity and unstable long-term dynamics inhibit …
  6. Accelerating scientific discovery with the common task framework

    Publication
    Machine learning (ML) and artificial intelligence (AI) algorithms are transforming and empowering the characterization and control of dynamic systems in the engineering, physical, and biological sciences. These emerging …
  7. Universal Spectral Tokenization via Self-Supervised Panchromatic Representation Learning

    Publication
    Sequential scientific data span many resolutions and domains, and unifying them into a common representation is a key step toward developing foundation models for the sciences. Astronomical spectra …
  8. AION-1: Omnimodal Foundation Model for Astronomical Sciences

    Publication
    While foundation models have shown promise across a variety of fields, astronomy still lacks a unified framework for joint modeling across its highly diverse data modalities. In this …
  9. Lost in Latent Space: An Empirical Study of Latent Diffusion Models for Physics Emulation

    Publication
    The steep computational cost of diffusion models at inference hinders their use as fast physics emulators. In the context of image and video generation, this computational drawback has …
  10. ASURA-FDPS-ML: Star-by-star Galaxy Simulations Accelerated by Surrogate Modeling for Supernova Feedback

    Publication
    We introduce new high-resolution galaxy simulations accelerated by a surrogate model that reduces the computation cost by approximately 75%. Massive stars with a zero-age main-sequence …
  11. Field-level emulation of cosmic structure formation with cosmology and redshift dependence

    Publication
    We present a field-level emulator for large-scale structure, capturing the cosmology dependence and the time evolution of cosmic structure formation. The emulator maps linear displacement fields …
  12. Spatial and temporal super-resolution methods for high-fidelity solar imaging

    Publication
    Context. The Sun plays a significant role in space weather by emitting energy and electromagnetic radiation that influence the environment around the Earth. Missions such as SOHO, STEREO …
  13. The Well: a Large-Scale Collection of Diverse Physics Simulations for Machine Learning

    Publication
    Machine learning based surrogate models offer researchers powerful tools for accelerating simulation-based workflows. However, as standard datasets in this space often cover small classes of physical behavior …
  14. The Multimodal Universe: Enabling Large-Scale Machine Learning with 100TB of Astronomical Scientific Data

    Publication
    We present the MULTIMODAL UNIVERSE, a large-scale multimodal dataset of scientific astronomical data, compiled specifically to facilitate machine learning research. Overall, the MULTIMODAL UNIVERSE contains hundreds of …
  15. The Multimodal Universe: 100 TB of Machine Learning Ready Astronomical Data

    Publication
    We present the Multimodal Universe, a new framework collating over 100 TB of multimodal astronomical data for its first release, spanning images, spectra, time series, tabular and hyper …
  16. Accelerating Giant-impact Simulations with Machine Learning

    Publication
    Constraining planet-formation models based on the observed exoplanet population requires generating large samples of synthetic planetary systems, which can be computationally prohibitive. A significant bottleneck is simulating …
  17. Cosmological constraints from non-Gaussian and nonlinear galaxy clustering using the SIMBIG inference framework

    Publication
    The standard ΛCDM cosmological model predicts the presence of cold dark matter, with the current accelerated expansion of the Universe driven by dark energy. This model has recently …
  18. Neutrino Mass Constraint from an Implicit Likelihood Analysis of BOSS Voids

    Publication
    Cosmic voids identified in the spatial distribution of galaxies provide complementary information to two-point statistics. In particular, constraints on the neutrino mass sum, \(\sum m_\nu\), promise …
  19. Cosmological constraints from the redshift-space galaxy skew spectra

    Publication
    Extracting the non-Gaussian information of the cosmic large-scale structure (LSS) is vital in unlocking the full potential of the rich datasets from the upcoming stage-IV …
  20. SimBIG: Cosmological Constraints using Simulation-Based Inference of Galaxy Clustering with Marked Power Spectra

    Publication
    We present the first \(\Lambda\)CDM cosmological analysis performed on a galaxy survey using marked power spectra. The marked power spectrum is the two-point function of a …
  21. Leaving No Branches Behind: Predicting Baryonic Properties of Galaxies from Merger Trees

    Publication
    Galaxies play a key role in our endeavor to understand how structure formation proceeds in the Universe. For any precision study of cosmology or galaxy formation, there is …
  22. Latent Stochastic Differential Equations for Modeling Quasar Variability and Inferring Black Hole Properties

    Publication
    Quasars are bright and unobscured active galactic nuclei (AGN) thought to be powered by the accretion of matter around supermassive black holes at the centers of galaxies. The …
  23. Field-level simulation-based inference of galaxy clustering with convolutional neural networks

    Publication
    We present the first simulation-based inference (SBI) of cosmological parameters from field-level analysis of galaxy clustering. Standard galaxy clustering analyses rely on analyzing summary statistics, such …
  24. Galaxy clustering analysis with SimBIG and the wavelet scattering transform

    Publication
    The non-Gaussisan spatial distribution of galaxies traces the large-scale structure of the Universe and therefore constitutes a prime observable to constrain cosmological parameters. We conduct Bayesian …
  25. Cosmological constraints from the nonlinear galaxy bispectrum

    Publication
    We present the first cosmological constraints from analyzing higher-order galaxy clustering on non-linear scales. We use \({\rm S{\scriptsize IM}BIG}\), a forward modeling framework for …
  26. Fast-forward FARGO: Accelerating Protoplanetary Disk Simulations with Limited Data

    Publication
    Hydrodynamic simulations of planets embedded in accretion disks around young stars are an essential tool in the study of planet formation and evolution. However, these simulations are expensive …
  27. Fast-forward {FARGO}: Accelerating Protoplanetary Disk Simulations with Limited Data

    Publication
    Hydrodynamic simulations of planets embedded in accretion disks around young stars are an essential tool in the study of planet formation and evolution. However, these simulations are expensive …
  28. Particle Clustering in Turbulence: Prediction of Spatial and Statistical Properties with Deep Learning

    Publication
    We investigate the utility of deep learning for modeling the clustering of particles that are aerodynamically coupled to turbulent fluids. Using a Lagrangian particle module within the Athena …
  29. Fast-forward {FARGO}: Accelerating Protoplanetary Disk Simulations with Limited Data

    Publication
    Hydrodynamic simulations of planets embedded in accretion disks around young stars are an essential tool in the study of planet formation and evolution. However, these simulations are expensive …
  30. Fast-forward {FARGO}: Accelerating Protoplanetary Disk Simulations with Limited Data

    Publication
    Hydrodynamic simulations of planets embedded in accretion disks around young stars are an essential tool in the study of planet formation and evolution. However, these simulations are expensive …
  31. Posterior sampling of the initial conditions of the universe from non-linear large scale structures using score-based generative models

    Publication
    Reconstructing the initial conditions of the universe is a key problem in cosmology. Methods based on simulating the forward evolution of the universe have provided a way to …
  32. Fast-forward {FARGO}: Accelerating Protoplanetary Disk Simulations with Limited Data

    Publication
    Hydrodynamic simulations of planets embedded in accretion disks around young stars are an essential tool in the study of planet formation and evolution. However, these simulations are expensive …
  33. Augmenting astrophysical scaling relations with machine learning: application to reducing the Sunyaev-Zeldovich flux-mass scatter

    Publication
    Complex astrophysical systems often exhibit low-scatter relations between observable properties (e.g., luminosity, velocity dispersion, oscillation period). These scaling relations illuminate the underlying physics, and can provide …
  34. Charting Galactic Accelerations with Stellar Streams and Machine Learning

    Publication
    We present a data-driven method for reconstructing the galactic acceleration field from phase-space measurements of stellar streams. Our approach is based on a flexible and differentiable …
  35. An exploration of the properties of cluster profiles for the thermal and kinetic Sunyaev–Zel’dovich effects

    Publication
    With the advent of high-resolution, low-noise CMB measurements, the ability to extract cosmological information from thermal Sunyaev-Zel'dovich effect and kinetic Sunyaev-Zel'dovich effect …
  36. Simple lessons from complex learning: what a neural network model learns about cosmic structure formation

    Publication
    We train a neural network model to predict the full phase space evolution of cosmological N-body simulations. Its success implies that the neural network model is accurately …
  37. Field Level Neural Network Emulator for Cosmological N-body Simulations

    Publication
    We build a field level emulator for cosmic structure formation that is accurate in the nonlinear regime. Our emulator consists of two convolutional neural networks trained to output …
  38. Cosmological Information in the Marked Power Spectrum of the Galaxy Field

    Publication
    Marked power spectra are two-point statistics of a marked field obtained by weighting each location with a function that depends on the local density around that point …
  39. Charting Galactic Accelerations with Stellar Streams and Machine Learning

    Publication
    We present a data-driven method for reconstructing the galactic acceleration field from phase-space measurements of stellar streams. Our approach is based on a flexible and differentiable …
  40. Wavelet Moments for Cosmological Parameter Estimation

    Publication
    Extracting non-Gaussian information from the non-linear regime of structure formation is key to fully exploiting the rich data from upcoming cosmological surveys probing the large-scale …
  41. A New Classification Model for the ZTF Catalog of Periodic Variable Stars

    Publication
    Using the second data release from the Zwicky Transient Facility (ZTF, Bellm et al. 2019), Chen et al. (2020) created a ZTF Catalog of Periodic Variable Stars (ZTF …
  42. A Convolutional Autoencoder-Based Pipeline for Anomaly Detection and Classification of Periodic Variables

    Publication
    The periodic pulsations of stars teach us about their underlying physical process. We present a convolutional autoencoder-based pipeline as an automatic approach to search for out-of …
  43. A Bayesian neural network predicts the dissolution of compact planetary systems

    Publication
    Despite over three hundred years of effort, no solutions exist for predicting when a general planetary configuration will become unstable. We introduce a deep learning architecture to push …
  44. A Bayesian neural network predicts the dissolution of compact planetary systems

    Publication
    Despite over three hundred years of effort, no solutions exist for predicting when a general planetary configuration will become unstable. We introduce a deep learning architecture to push …
  45. A Deep-learning Approach for Live Anomaly Detection of Extragalactic Transients

    Publication
    There is a shortage of multiwavelength and spectroscopic follow-up capabilities given the number of transient and variable astrophysical events discovered through wide-field optical surveys such as …
  46. Learning the Evolution of the Universe in N-body Simulations

    Publication
    Understanding the physics of large cosmological surveys down to small (nonlinear) scales will significantly improve our knowledge of the Universe. Large N-body simulations have been built to …
  47. Fast and Accurate Non-Linear Predictions of Universes with Deep Learning

    Publication
    Cosmologists aim to model the evolution of initially low amplitude Gaussian density fluctuations into the highly non-linear "cosmic web" of galaxies and clusters. They aim to compare …
  48. Anomaly Detection for Multivariate Time Series of Exotic Supernovae

    Publication
    Supernovae mark the explosive deaths of stars and enrich the cosmos with heavy elements. Future telescopes will discover thousands of new supernovae nightly, creating a need to flag …
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