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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

  • All News
  • Research News
  • Funding Announcements
  • Newsletter Sign Up
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  • Media Relations

We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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  • Presidential Lectures
  • Presents
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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Polygenic and developmental profiles of autism differ by age at diagnosis.

    Publication
  2. Sex differences in human brain structure at birth.

    Publication
  3. Using organoids to model sex differences in the human brain.

    Publication
  4. Moral foundations in autistic people and people with systemizing minds.

    Publication
  5. Increased rates of chronic physical health conditions across all organ systems in autistic adolescents and adults.

    Publication
  6. A qualitative exploration of autistic mothers' experiences I: Pregnancy experiences.

    Publication
  7. Are autistic people disadvantaged by the criminal justice system? A case comparison.

    Publication
  8. Autistic people's perinatal experiences II: A survey of childbirth and postnatal experiences.

    Publication
  9. Phenotypic effects of genetic variants associated with autism.

    Publication
  10. Identifying rare genetic variants in 21 highly multiplex autism families: The role of diagnosis and autistic traits.

    Publication
  11. Processing of social and monetary rewards in autism spectrum disorders.

    Publication
  12. The impact of quality control on cortical morphometry comparisons in autism.

    Publication
  13. Autism incidence and spatial analysis in more than 7 million pupils in English schools: A retrospective, longitudinal, school registry study.

    Publication
  14. Cerebellar atypicalities in autism?

    Publication
  15. Oxytocin enhances basolateral amygdala activation and functional connectivity while processing emotional faces: Preliminary findings in autistic vs non-autistic women.

    Publication
  16. Reexamining empathy in autism: Empathic disequilibrium as a novel predictor of autism diagnosis and autistic traits.

    Publication
  17. Autistic mothers' perinatal well-being and parenting styles.

    Publication
  18. Autism is associated with interindividual variations of gray and white matter morphology.

    Publication
  19. Genetic correlates of phenotypic heterogeneity in autism.

    Publication
  20. Evaluation of data imputation strategies in complex, deeply-phenotyped data sets: The case of the EU-AIMS Longitudinal European Autism Project.

    Publication
  21. Digit ratio (2D:4D) and maternal testosterone-to-estradiol ratio measured in early pregnancy.

    Publication
  22. Autistic adults have poorer quality healthcare and worse health based on self-report data.

    Publication
  23. Evidence of partner similarity for autistic traits, systemizing, and theory of mind via facial expressions.

    Publication
  24. Resting state EEG power spectrum and functional connectivity in autism: A cross-sectional analysis.

    Publication
  25. Autism and the criminal justice system: An analysis of 93 cases.

    Publication
  26. Fine-grained topographic organization within somatosensory cortex during resting-state and emotional face-matching task and its association with ASD traits.

    Publication
  27. The link between autism and sex-specific neuroanatomy, and associated cognition and gene expression.

    Publication
  28. The relevance of the interpersonal theory of suicide for predicting past-year and lifetime suicidality in autistic adults.

    Publication
  29. The effect of autistic traits on disembedding and mental rotation in neurotypical women and men.

    Publication
  30. Visual consciousness dynamics in adults with and without autism.

    Publication
  31. Polygenic scores for empathy associate with posttraumatic stress severity in response to certain traumatic events.

    Publication
  32. Is there an association between prenatal testosterone and autistic traits in adolescents?

    Publication
  33. Autism screening at 18 months of age: A comparison of the Q-CHAT-10 and M-CHAT screeners.

    Publication
  34. Preference for biological motion is reduced in ASD: Implications for clinical trials and the search for biomarkers.

    Publication
  35. Maternal steroid levels and the autistic traits of the mother and infant.

    Publication
  36. Imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry.

    Publication
  37. An investigation of the diet, exercise, sleep, BMI, and health outcomes of autistic adults.

    Publication
  38. Sex differences in brain development in fetuses and infants who are at low or high likelihood for autism.

    Publication
  39. Towards robust and replicable sex differences in the intrinsic brain function of autism.

    Publication
  40. Fractionating autism based on neuroanatomical normative modeling.

    Publication
  41. Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women.

    Publication
  42. Large-scale analyses of the relationship between sex, age and intelligence quotient heterogeneity and cortical morphometry in autism spectrum disorder.

    Publication
  43. Social and non-social autism symptoms and trait domains are genetically dissociable.

    Publication

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