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  1. Learning shapes cortical dynamics to enhance integration of relevant sensory input

    Publication
    Adaptive sensory behavior is thought to depend on processing in recurrent cortical circuits, but how dynamics in these circuits shapes the integration and transmission of sensory information is …

  2. The caudal prethalamus: Inhibitory switchboard for behavioral control?

    Publication
    Prethalamic nuclei in the mammalian brain include the zona incerta, the ventral lateral geniculate nucleus, and the intergeniculate leaflet, which provide long-range inhibition to many targets in …

  3. Dynamic causal communication channels between neocortical areas

    Publication
    Processing of sensory information depends on the interactions between hierarchically connected neocortical regions, but it remains unclear how the activity in one area causally influences the activity dynamics …

  4. Learning and attention increase visual response selectivity through distinct mechanisms

    Publication
    Selectivity of cortical neurons for sensory stimuli can increase across days as animals learn their behavioral relevance and across seconds when animals switch attention. While both phenomena occur …

  5. A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging

    Publication
    Inference of action potentials ('spikes') from neuronal calcium signals is complicated by the scarcity of simultaneous measurements of action potentials and calcium signals ('ground truth'). In this study …

  6. A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging

    Publication
    Inference of action potentials ('spikes') from neuronal calcium signals is complicated by the scarcity of simultaneous measurements of action potentials and calcium signals ('ground truth'). In this study …

  7. Visual intracortical and transthalamic pathways carry distinct information to cortical areas

    Publication
    Sensory processing involves information flow between neocortical areas, assumed to rely on direct intracortical projections. However, cortical areas may also communicate indirectly via higher-order nuclei in the …

  8. Standardized and reproducible measurement of decision-making in mice

    Publication
    Progress in science requires standardized assays whose results can be readily shared, compared, and reproduced across laboratories. Reproducibility, however, has been a concern in neuroscience, particularly for measurements …

  9. Contextual signals in visual cortex.

    Publication
    Vision is an active process. What we perceive strongly depends on our actions, intentions and expectations. During visual processing, these internal signals therefore need to be integrated with …

  10. Distinct learning-induced changes in stimulus selectivity and interactions of GABAergic interneuron classes in visual cortex.

    Publication
    How learning enhances neural representations for behaviorally relevant stimuli via activity changes of cortical cell types remains unclear. We simultaneously imaged responses of pyramidal cells (PYR) along with …