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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. New Omics Data Available From Autism BrainNet

    September 3, 2026
    Autism BrainNet (ABN) announces the release of genetic data from the laboratories of Tomasz Nowakowski and Stephan Sanders. This release includes omics data from studies of postmortem brain …
  2. Genes Linked to Early Childhood Temperament Also Influence Autism and ADHD Risk

    August 31, 2026
    … distinction lets researchers separate genetics from environment. A sibling with more of the genetic variants linked to a trait, such as shyness, tended to score higher on …
  3. SFARI Sex Differences Collaborations Convene for Fourth Annual Meeting

    June 18, 2026
    … reported that measures of gene expression and chromatin accessibility across the genome followed patterns specific to the XX or XY status of an individual cell, regardless of …
  4. 2026 SFARI Sex Differences Collaborations Announced

    April 2, 2026
    These awards support interdisciplinary research into the sex bias associated with autism and its underlying biological mechanisms.
  5. SFARI Sex Differences Collaboration Gathers for Third Annual Meeting

    April 23, 2025
    On January 27–28, the Simons Foundation held the third annual meeting of the SFARI Sex Differences Collaboration (SSDC). Formed in 2021, this collaboration seeks to understand the …
  6. SFARI Sex Differences Collaboration Shares Findings at Second Annual Meeting

    May 17, 2024
    On January 8–9, 2024, SFARI welcomed researchers to its second annual meeting of the SFARI Sex Differences Collaboration (SSDC).
  7. SFARI Sex Differences Collaboration Gather To Share Their Progress

    June 1, 2023
    On January 30–31, SFARI convened its first annual meeting of the SFARI Sex Differences Collaboration (SSDC). Funded in 2021, the SSDC collaboration consists of five groups of …
  8. SFARI 2021 Director Awards Announced

    January 27, 2022
    SFARI is pleased to announce that seven Director Awards were awarded in 2021. These projects include, but are not limited to, studies that aim to develop new tools …
  9. 2020 SFARI Collaboration on Sex Differences in Autism Awardees Announced

    July 29, 2021
    SFARI is pleased to announce that it intends to fund five collaborative groups in response to the 2020 SFARI Collaboration on Sex Differences in Autism request for applications.
  10. SFARI Workshop Explores Challenges and Opportunities of Gene Therapies for Autism Spectrum Disorder

    June 24, 2020
    On February 6–7, 2020, SFARI convened a two-day workshop to explore the possibility of gene therapies for autism spectrum disorder.
  11. Mutations in Uncharted Territory

    April 29, 2020
    Genetic dark matter makes up 98 percent of our genomes, yet scientists are still figuring out how it works.
  12. Inventing Tools for Others: Supercharging Studies of Autism Genetics

    March 19, 2020
    To speed discovery, SFARI decided to break the traditional approach in which each laboratory collects its own datasets and keeps them close to the vest.
  13. SFARI Summer 2019 Pilot Awardees Announced

    September 30, 2019
    SFARI is pleased to announce that is intends to fund 12 grants in response to the Summer 2019 Pilot Award request for applications.
  14. Unexpected Synaptic Role for the Autism Risk Gene Scn2a

    July 26, 2019
    Kevin Bender, Stephan Sanders and colleagues show that there is an unexpectedly critical role for the autism risk gene Scn2a, which encodes the sodium channel NaV1.2, in …
  15. Cryptic Splice Mutations: A Major New Source of Risk Variants for Neurodevelopmental Disorders

    March 20, 2019
    Kyle Kai-How Farh and Stephan Sanders developed a deep-learning method to predict risk mutations that affect mRNA splicing and contribute substantially to neurodevelopmental disorders.
  16. Large-Scale SSC Whole-Genome Sequencing Data Key to Identifying Statistically Significant De Novo Noncoding Variation in Autism

    February 25, 2019
    Stephan Sanders and colleagues used a machine learning approach to analyze whole-genome sequencing data from more than 1,900 SSC families and found that de novo noncoding …
  17. Noncoding Mutations Contribute to Autism Risk

    December 13, 2018
    Genome-wide analysis the first to uncover a role for mutations in the noncoding portion of the genome in any human condition
  18. SFARI 2018 Pilot and Research Awardees Announced

    September 10, 2018
    SFARI is pleased to announce that it intends to fund 36 grants (15 Pilot Awards and 21 Research Awards) in response to the 2018 Pilot and Research Awards …
  19. SFARI Spring 2018 Science Meeting Discussed Latest Developments in Autism Research

    September 7, 2018
    SFARI held its thirteenth science meeting April 8–12, 2018. SFARI investigators, collaborators and foundation staff came together to discuss recent findings in autism genetics, molecular and system …

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