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  1. Deep learning for neural decoding in motor cortex

    Publication
    … network containing the concurrent ANN decoder outperformed single-network concurrent decoders.Significance. Taken together, our study demonstrates that deep learning could become a robust and effective method …

  2. Learning binds new inputs into functional synaptic clusters via spinogenesis

    Publication
    Learning induces the formation of new excitatory synapses in the form of dendritic spines, but their functional properties remain unknown. Here, using longitudinal in vivo two-photon imaging …

  3. Learning binds new inputs into functional synaptic clusters via spinogenesis

    Publication
    Learning induces the formation of new excitatory synapses in the form of dendritic spines, but their functional properties remain unknown. Here, using longitudinal in vivo two-photon imaging …

  4. Global and subtype-specific modulation of cortical inhibitory neurons regulated by acetylcholine during motor learning

    Publication
    Inhibitory neurons (INs) consist of distinct subtypes with unique functions. Previous studies on INs mainly focused on single brain regions, and thus it remains unclear whether the modulation …

  5. PatchWarp: Corrections of non-uniform image distortions in two-photon calcium imaging data by patchwork affine transformations

    Publication
    Complex distortions on calcium imaging often impair image registration accuracy. Here, we developed a registration algorithm, PatchWarp, to robustly correct slow image distortion for calcium imaging data. PatchWarp …

  6. Longitudinal two-photon calcium imaging with ultra-large cranial window for head-fixed mice

    Publication
    Neural activity is heterogeneous across different cortical areas and can change during learning. Here, we describe a protocol for longitudinal in vivo two-photon calcium imaging with an …

  7. Wide-field calcium imaging of cortex-wide activity in awake, head-fixed mice

    Publication
    Characterizing cortex-wide neural activity is essential for understanding large-scale interactions among distributed cortical regions. Here, we describe a protocol using wide-field calcium imaging to monitor …

  8. Context-dependent persistency as a coding mechanism for robust and widely distributed value coding

    Publication
    Task-related information is widely distributed across the brain with different coding properties, such as persistency. We found in mice that coding persistency of action history and value …