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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Visual and motor signatures of locomotion dynamically shape a population code for feature detection in Drosophila

    Publication
  2. Glial control of sphingolipid levels sculpts diurnal remodeling in a circadian circuit

    Publication
  3. Sustained deep-tissue voltage recording using a fast indicator evolved for two-photon microscopy

    Publication
    Genetically encoded voltage indicators are emerging tools for monitoring voltage dynamics with cell-type specificity. However, current indicators enable a narrow range of applications due to poor performance …
  4. Mechanosensory input during circuit formation shapes Drosophila motor behavior through patterned spontaneous network activity

    Publication
    Neural activity sculpts circuit wiring in many animals. In vertebrates, patterned spontaneous network activity (PaSNA) generates sensory maps and establishes local circuits.1-3 However, it remains unclear …
  5. Coupling of activity, metabolism and behaviour across the Drosophila brain

    Publication
    Coordinated activity across networks of neurons is a hallmark of both resting and active behavioural states in many species1-5. These global patterns alter energy metabolism over seconds …
  6. The connectome predicts resting-state functional connectivity across the Drosophila brain

    Publication
    Anatomical connectivity can constrain both a neural circuit's function and its underlying computation. This principle has been demonstrated for many small, defined neural circuits. For example, connectome …
  7. Sequential Nonlinear Filtering of Local Motion Cues by Global Motion Circuits.

    Publication
    Many animals guide their movements using optic flow, the displacement of stationary objects across the retina caused by self-motion. How do animals selectively synthesize a global motion …
  8. Linear Summation Underlies Direction Selectivity in Drosophila.

    Publication
    While linear mechanisms lay the foundations of feature selectivity in many brain areas, direction selectivity in the elementary motion detector (EMD) of the fly has become a paradigm …
  9. Elementary Motion Detection in Drosophila: Algorithms and Mechanisms.

    Publication
    Motion in the visual world provides critical information to guide the behavior of sighted animals. Furthermore, as visual motion estimation requires comparisons of signals across inputs and over …
  10. Drosophila Connectomics: Mapping the Larval Eye's Mind.

    Publication
    A new study has mapped the connectome - the shapes and connections of all the neurons- of the visual system of a Drosophila larva, providing a structural basis for …

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