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  1. Engulfment by brain macrophages in a short-lived vertebrate.

    Publication
    Engulfment by macrophages is critical for waste clearance in the vertebrate brain. Understanding clearance mechanisms may open new therapeutic possibilities to counter brain aging and neurodegenerative diseases. However …

  2. Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition.

    Publication
    The immune system could play an important role in the age-related decline in brain function, yet specific immune-based strategies to enhance brain resilience in older individuals …

  3. Ageing promotes microglial accumulation of slow-degrading synaptic proteins.

    Publication
    Neurodegenerative diseases affect 1 in 12 people globally and remain incurable. Central to their pathogenesis is a loss of neuronal protein maintenance and the accumulation of protein aggregates …

  4. Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain

    Publication

  5. Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment

    Publication

  6. An automated feeding system for the African killifish reveals effects of dietary restriction on lifespan and allows scalable assessment of associative learning

    Publication

  7. Microglia states and nomenclature: A field at its crossroads

    Publication

  8. Microglia states and nomenclature: A field at its crossroads

    Publication

  9. Postmortem Human Dura Mater Cells Exhibit Phenotypic, Transcriptomic and Genetic Abnormalities that Impact their Use for Disease Modeling

    Publication
    Patient-derived cells hold great promise for precision medicine approaches in human health. Human dermal fibroblasts have been a major source of cells for reprogramming and differentiating into …

  10. Unraveling protein dynamics to understand the brain - the next molecular frontier

    Publication
    The technological revolution to measure global gene expression at the single-cell level is currently transforming our knowledge of the brain and neurological diseases, leading from a basic …

  11. Measuring biological age using omics data

    Publication
    Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-related diseases and increase healthspan have suggested targeting the ageing process …

  12. The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

    Publication
    Molecular characterization of cell types using single-cell transcriptome sequencing is revolutionizing cell biology and enabling new insights into the physiology of human organs. We created a human …

  13. Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17

    Publication
    Recent understanding of how the systemic environment shapes the brain throughout life has led to numerous intervention strategies to slow brain ageing1-3. Cerebrospinal fluid (CSF) makes up …

  14. Limited proteolysis–mass spectrometry reveals aging-associated changes in cerebrospinal fluid protein abundances and structures

    Publication
    Cerebrospinal fluid (CSF) proteins and their structures have been implicated in aging and neurodegenerative diseases. In the present study, we used limited proteolysis–mass spectrometry (LiP–MS) to …

  15. KL1 Domain of Longevity Factor Klotho Mimics the Metabolome of Cognitive Stimulation and Enhances Cognition in Young and Aging Mice

    Publication
    … cognitive deficits. We demonstrate that brain engagement through cognitive stimulation induces metabolic remodeling of the hippocampus that was acutely recapitulated by the longevity factor klotho, mediated by …

  16. Treatment of a genetic brain disease by CNS-wide microglia replacement

    Publication
    Hematopoietic cell transplantation after myeloablative conditioning has been used to treat various genetic metabolic syndromes but is largely ineffective in diseases affecting the brain presumably due to poor …

  17. Small molecule C381 targets the lysosome to reduce inflammation and ameliorate disease in models of neurodegeneration

    Publication
    SignificanceNeurodegenerative diseases are poorly understood and difficult to treat. One common hallmark is lysosomal dysfunction leading to the accumulation of aggregates and other undegradable materials, which cause damage …

  18. Molecular hallmarks of heterochronic parabiosis at single-cell resolution

    Publication
    The ability to slow or reverse biological ageing would have major implications for mitigating disease risk and maintaining vitality1. Although an increasing number of interventions show promise for …

  19. A human brain vascular atlas reveals diverse mediators of Alzheimer's risk

    Publication
    The human brain vasculature is of great medical importance: its dysfunction causes disability and death1, and the specialized structure it forms-the blood-brain barrier-impedes the treatment …

  20. Exercise plasma boosts memory and dampens brain inflammation via clusterin

    Publication
    Physical exercise is generally beneficial to all aspects of human and animal health, slowing cognitive ageing and neurodegeneration1. The cognitive benefits of physical exercise are tied to an …

  21. Genome-wide analysis of common and rare variants via multiple knockoffs at biobank scale, with an application to Alzheimer disease genetics

    Publication
    Knockoff-based methods have become increasingly popular due to their enhanced power for locus discovery and their ability to prioritize putative causal variants in a genome-wide analysis …

  22. An oligomeric semiconducting nanozyme with ultrafast electron transfers alleviates acute brain injury

    Publication

  23. CD4 + T cells contribute to neurodegeneration in Lewy body dementia

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  24. Genome-wide analysis of common and rare variants via multiple knockoffs at biobank scale, with an application to Alzheimer disease genetics

    Publication
    Knockoff-based methods have become increasingly popular due to their enhanced power for locus discovery and their ability to prioritize putative causal variants in a genome-wide analysis …

  25. miRNATissueAtlas2: an update to the human miRNA tissue atlas

    Publication
    Small non-coding RNAs (sncRNAs) are pervasive regulators of physiological and pathological processes. We previously developed the human miRNA Tissue Atlas, detailing the expression of miRNAs across organs …

  26. Peripheral B-cells repress B-cell regeneration in aging through a TNFα/IGFBP-1/IGF1 immune-endocrine axis

    Publication
    Loss of B lymphocyte regeneration in the bone marrow (BM) is an immunological hallmark of advanced age, which impairs the replenishment of peripheral B-cell subsets and results …

  27. Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues

    Publication
    Brain endothelial cells (BECs) are key constituents of the blood-brain barrier (BBB), protecting the brain from pathogens and restricting access of circulatory factors. Yet, because circulatory proteins …

  28. Methods to investigate intrathecal adaptive immunity in neurodegeneration

    Publication
    Background: Cerebrospinal fluid (CSF) provides basic mechanical and immunological protection to the brain. Historically, analysis of CSF has focused on protein changes, yet recent studies have shed light …

  29. Asynchronous, contagious and digital aging

    Publication
    Aging has largely been defined by analog measures of organ and organismal dysfunction. This has led to the characterization of aging processes at the molecular and cellular levels …

  30. CoolMPS for robust sequencing of single-nuclear RNAs captured by droplet-based method

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    Massively-parallel single-cell and single-nucleus RNA sequencing (scRNA-seq, snRNA-seq) requires extensive sequencing to achieve proper per-cell coverage, making sequencing resources and availability of …

  31. Common diseases alter the physiological age-related blood microRNA profile

    Publication
    Aging is a key risk factor for chronic diseases of the elderly. MicroRNAs regulate post-transcriptional gene silencing through base-pair binding on their target mRNAs. We identified …

  32. Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging

    Publication
    We previously identified 529 proteins that had been reported by multiple different studies to change their expression level with age in human plasma. In the present study, we …

  33. Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age

    Publication
    Adipose tissue eosinophils (ATEs) are important in the control of obesity-associated inflammation and metabolic disease. However, the way in which ageing impacts the regulatory role of ATEs …

  34. Physiological blood-brain transport is impaired with age by a shift in transcytosis

    Publication
    The vascular interface of the brain, known as the blood-brain barrier (BBB), is understood to maintain brain function in part via its low transcellular permeability1-3. Yet …

  35. Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration

    Publication
    A rapidly ageing population and a limited therapeutic toolbox urgently necessitate new approaches to treat neurodegenerative diseases. Brain ageing, the key risk factor for neurodegeneration, involves complex cellular …

  36. Single-cell analysis reveals T cell infiltration in old neurogenic niches

    Publication
    The mammalian brain contains neurogenic niches that comprise neural stem cells and other cell types. Neurogenic niches become less functional with age, but how they change during ageing …