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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Towards the cellular-scale simulation of motor-driven cytoskeletal assemblies

    Publication
    The cytoskeleton -- a collection of polymeric filaments, molecular motors, and crosslinkers -- is a foundational example of active matter, and in the cell assembles into organelles that guide basic …
  2. Euchromatin activity enhances segregation and compaction of heterochromatin in the cell nucleus

    Publication
    The large-scale organization of the genome inside the cell nucleus is critical for the cell’s function. Chromatin – the functional form of DNA in cells – serves as …
  3. Understanding topological defects in fluidized dry active nematics

    Publication
    Dense assemblies of self-propelling rods (SPRs) may exhibit fascinating collective behaviors and anomalous physical properties that are far away from equilibrium. Using large-scale Brownian dynamics simulations …
  4. Kernel Aggregated Fast Multipole Method: Efficient summation of Laplace and Stokes kernel functions

    Publication
    Many different simulation methods for Stokes flow problems involve a common computationally intense task—the summation of a kernel function over O(N2) pairs of points. One popular …
  5. A scalable computational platform for Stokes suspensions

    Publication
    We describe a computational framework for simulating suspensions of rigid particles in Newtonian Stokes flow. One central building block is a collision-resolution algorithm that overcomes the numerical …
  6. Scaling law of Brownian rotation in dense hard-rod suspensions

    Publication
    Self-diffusion in dense rod suspensions are subject to strong geometric constraints because of steric interactions. This topological effect is essentially anisotropic when rods are nematically aligned with …
  7. Complex dynamics of long, flexible fibers in shear

    Publication
    The macroscopic properties of polymeric fluids are inherited from the material properties of the fibers embedded in the solvent. The behavior of such passive fibers in flow has …
  8. Computing collision stress in assemblies of active spherocylinders: applications of a fast and generic geometric method

    Publication
    In this work, we provide a solution to the problem of computing collision stress in particle-tracking simulations. First, a formulation for the collision stress between particles is …
  9. Universal image systems for non-periodic and periodic Stokes flows above a no-slip wall

    Publication
    It is well-known that by placing judiciously chosen image point forces and doublets to the Stokeslet above a flat wall, the no-slip boundary condition can be …
  10. Anisotropic swim stress in active matter with nematic order

    Publication
  11. Universal image systems for non-periodic and periodic Stokes flows above a no-slip wall

    Publication
    It is well-known that by placing judiciously chosen image point forces and doublets to the Stokeslet above a flat wall, the no-slip boundary condition can be …
  12. Flexibly imposing periodicity in kernel independent FMM: A multipole-to-local operator approach

    Publication
    An important but missing component in the application of the kernel independent fast multipole method (KIFMM) is the capability for flexibly and efficiently imposing singly, doubly, and triply …
  13. Connecting macroscopic dynamics with microscopic properties in active microtubule network contraction

    Publication
    The cellular cytoskeleton is an active material, driven out of equilibrium by molecular motor proteins. It is not understood how the collective behaviors of cytoskeletal networks emerge from …
  14. The Curved Kinetic Boundary Layer of Active Matter

    Publication
    A body submerged in active matter feels the swim pressure through a kinetic accumulation boundary layer on its surface. The boundary layer results from a balance between translational …
  15. Antiswarming: Structure and dynamics of repulsive chemically active particles

    Publication
    Chemically active Brownian particles with surface catalytic reactions may repel each other due to diffusiophoretic interactions in the reaction and product concentration fields. The system behavior can be …

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