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  1. A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A

    Publication

  2. Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation

    Publication

  3. High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity

    Publication
    Mitochondrial dysfunction is a well-known contributor to aging and age-related diseases. The precise mechanisms through which mitochondria impact human lifespan, however, remain unclear. We hypothesize that …

  4. Meeting Report: Aging Research and Drug Discovery

    Publication
    Aging is the single largest risk factor for most chronic diseases, and thus possesses large socioeconomic interest to continuously aging societies. Consequently, the field of aging research is …

  5. Pregnancy, preeclampsia and maternal aging: From epidemiology to functional genomics

    Publication
    Women live longer than men but experience greater disability and a longer period of illness as they age. Despite clear sex differences in aging, the impact of pregnancy …

  6. Novel small molecule inhibition of IKK/NF-κB activation reduces markers of senescence and improves healthspan in mouse models of aging

    Publication
    Constitutive NF-κB activation is associated with cellular senescence and stem cell dysfunction and rare variants in NF-κB family members are enriched in centenarians. We recently identified …

  7. A Compendium of Age-Related PheWAS and GWAS Traits for Human Genetic Association Studies, Their Networks and Genetic Correlations

    Publication

  8. Age-related telomere attrition causes aberrant gene expression in sub-telomeric regions

    Publication
    Telomere attrition has been proposed as a biomarker and causal factor in aging. In addition to causing cellular senescence and apoptosis, telomere shortening has been found to affect …

  9. Transcriptome analysis reveals the difference between "healthy" and "common" aging and their connection with age-related diseases

    Publication
    A key goal of aging research was to understand mechanisms underlying healthy aging and develop methods to promote the human healthspan. One approach is to identify gene regulations …

  10. Transcriptome analysis reveals the difference between "healthy" and "common" aging and their connection with age-related diseases

    Publication
    A key goal of aging research was to understand mechanisms underlying healthy aging and develop methods to promote the human healthspan. One approach is to identify gene regulations …