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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Rigbox: An Open-Source Toolbox for Probing Neurons and Behavior

    Publication
    Setting up an experiment in behavioral neuroscience is a complex process that is often managed with ad hoc solutions. To streamline this process, we developed Rigbox, a high …
  2. A map of object space in primate inferotemporal cortex

    Publication
    The inferotemporal (IT) cortex is responsible for object recognition, but it is unclear how the representation of visual objects is organized in this part of the brain. Areas …
  3. Quantum process tomography with unsupervised learning and tensor networks

    Publication
    The impressive pace of advance of quantum technology calls for robust and scalable techniques for the characterization and validation of quantum hardware. Quantum process tomography, the reconstruction of …
  4. A Larger Extent for the Ophiuchus Stream

    Publication
    stream membership probabilities, resulting in the detection of more than 200 likely members. These data show the stream extends to more than three times the length shown in …
  5. Inference of Bacterial Small RNA Regulatory Networks and Integration with Transcription Factor-Driven Regulatory Networks

    Publication
    Small noncoding RNAs (sRNAs) are key regulators of bacterial gene expression. Through complementary base pairing, sRNAs affect mRNA stability and translation efficiency. Here, we describe a network inference …
  6. The impact of learning on perceptual decisions and its implication for speed-accuracy tradeoffs.

    Publication
    In standard models of perceptual decision-making, noisy sensory evidence is considered to be the primary source of choice errors and the accumulation of evidence needed to overcome …
  7. Autism-associated Shank3 is essential for homeostatic compensation in rodent V1.

    Publication
  8. Trapping, gliding, vaulting: transport of semiflexible polymers in periodic post arrays

    Publication
    The transport of deformable particles through porous media underlies a wealth of applications ranging from filtration to oil recovery to the transport and spreading of biological agents. Using …
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