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Bringing people and ideas together to fund, conduct, and share transformative science.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Muon Colliders: A new direction in High Energy Physics

    Funded Work
    In particle physics, the 10 TeV scale has emerged as the next target in the exploration of the energy frontier.
  2. Central American-Caribbean Bridge in Astrophysics

    Funded Work
    The Central American-Caribbean Bridge in Astrophysics (Cenca Bridge), an award-winning international nonprofit organization, provides opportunities to students from Central America and the Caribbean, where scientific research …
  3. Determining the molecular function of autism risk gene deleted in autism 1

    Funded Work
    Hypoxia-inducible factor (HIF), which consists of a labile HIFa subunit and stable HIFb (ARNT) subunit, is a master transcription factor that activates genes whose products promote adaptation …
  4. The role of microglia on aberrant neuronal network formation in autism spectrum disorder

    Funded Work
    Changes in microglia, the immune cells of the brain, have been recognized in brain tissue of individuals with autism spectrum disorders (ASD) for over 15 years, but it …
  5. Linking ASD risk genes to sensorimotor circuits for dynamic social communication

    Funded Work
    Autism can occur in isolation or as part of a syndrome which includes other neurodevelopmental disorders.
  6. Linking ASD risk genes to sensorimotor circuits for dynamic social

    Funded Work
    Autism spectrum disorder (ASD) is a heritable neurodevelopmental condition marked by deficits in social communication.
  7. Epigenetic regulators ASH1L and SETBP1 in GABAergic neuron development and autism spectrum disorder

    Funded Work
    Autism spectrum disorders (ASDs) are associated with disruptions in the development and function of GABAergic neurons1, which are critical for maintaining the balance of excitation and inhibition in …
  8. Convergent mechanisms underlying the expression of long autism risk genes and their effects on cortical circuit function

    Funded Work
    While autism (ASD) is a heterogeneous disorder, a significant fraction of ASD genetic risk is conferred by genes encoding for relatively selective functions, including synaptic proteins, and regulators …
  9. The connectome of developing circuits in mouse models of autism

    Funded Work
    Proper brain function relies on the precise formation of neural circuits during development.
  10. Neuronal mechanisms for differences in sound processing in mouse models of autism

    Funded Work
    Autism spectrum disorder (ASD) is associated with auditory hypersensitivity and auditory processing disorders.
  11. Identifying functional convergence of autism risk genes in regulating sodium channel membrane trafficking

    Funded Work
    Dysregulation of voltage-gated sodium channels (VGSC) is a prominent risk factor for autism spectrum disorder (ASD).
  12. Exploring the potential spinal origins of motor phenotypes in mouse models of autism

    Funded Work
    Autism spectrum disorder (ASD) is a neurodevelopmental condition that is frequently characterized by movement disorders, including stereotyped repetitive hand movements, difficulties with gait, balance, and coordination, and delays …
  13. Exploring the potential spinal origins of motor phenotypes in mouse models of autism

    Funded Work
    Autism spectrum disorder (ASD) is a neurodevelopmental disease that is frequently characterized by movement disorders, including stereotyped repetitive hand movements, difficulties with gait, balance, and coordination, and delays …
  14. Multimodal synaptic profiling of patient-derived neuronal samples for the discovery of ASD therapeutics

    Funded Work
    Neurons derived from induced pluripotent stem cells (iPSCs) from individuals with autism offer the singular avenue to directly test novel therapeutic compounds for efficacy in treating autism spectrum …
  15. The function of circular RNAs in fragile X syndrome

    Funded Work
    Fragile X syndrome (FXS) is the most frequent monogenic cause of autism spectrum disorder (ASD).
  16. Canonical computations in humans and mouse models of autism

    Funded Work
    Individuals with autism spectrum disorder (ASD) show varied phenotypes across social, communicative, sensory and motor domains.
  17. A pilot platform for restoring autism gene expression

    Funded Work
    There are hundreds of neurodevelopmental disorder (NDD) syndromes that cause autism because of the insufficient production of protein due to de novo mutations of specific genes.
  18. ASD gene therapy: Large-scale evaluation of small-molecule targeting of RNA for ASD therapeutics

    Funded Work
    Large-scale genetic studies have identified hundreds of genes associated with autism spectrum disorder (ASD).
  19. The impact of autism risk genes on oromotor behaviors

    Funded Work
    Difficulties with oromotor behaviors, like speech and feeding, are daily challenges for many individuals with autism.
  20. Gut-intrinsic mechanisms of gastrointestinal dysmotility in animal models of autism

    Funded Work
    The digestive distress that commonly accompanies autism spectrum disorder (ASD) significantly degrades the quality of life of those affected and their families1.
  21. Parvalbumin interneuron deficits in MTORpathies associated with ASD

    Funded Work
    Autism spectrum disorder (ASD) is often linked to mutations in genes regulating synaptic development and mRNA translation, implicating synaptic connectivity in its pathogenesis.
  22. Targeting converging exons to treat autism spectrum disorders

    Funded Work
    Alternative splicing shows a unique profile in the brain and the dysregulation of alternative splicing networks has been repeatedly reported in autistic brains.
  23. Placental neurosteroids in autism

    Funded Work
    Placental dysfunction is highly associated with abnormal fetal brain development and neurodevelopmental disorders such as autism.
  24. Circuit mechanisms mediating social attachment deficits in ASD

    Funded Work
    Disruptions in social attachment and cognition occur in the context of autism spectrum disorder (ASD).
  25. The role of the LC-NE system in perceptual deficits in a SHANK3 mouse model

    Funded Work
    Atypical sensory processing is widely observed in individuals with autism spectrum disorder (ASD) although the underlying biological mechanisms are unknown.
  26. Testing computational theories of visual processing in ASD with a novel integrated approach

    Funded Work
    A fundamental function of sensory systems is to segment sensory inputs into distinct perceptual objects (termed perceptual grouping and segmentation, PGS).
  27. SCOPE Synthesis: Causes and consequences of a shifting iron cycle in the North Pacific during the SCOPE era

    Funded Work
  28. Elucidating the unknown mechanisms of viral resistance in algal blooms in the ocean

    Funded Work
  29. SCOPE Synthesis: Emerging patterns in the diversity, activity, and community interactions of marine nitrogen fixers

    Funded Work
  30. SCOPE Synthesis: Synthesis of microbial biogeochemical results from SCOPE

    Funded Work
  31. SCOPE Synthesis: Metabolomics as a tool for understanding microbial communities of the North Pacific

    Funded Work
  32. SCOPE Synthesis: Causes and consequences of a shifting iron cycle in the North Pacific during the SCOPE era

    Funded Work
  33. SCOPE Synthesis: SCOPE ALOHA ‘omics time-series analyses and cruise integration analyzing marine picoplankton in the North Pacific Subtropical Gyre

    Funded Work
  34. SCOPE Synthesis: Phytoplankton interaction networks along Gradients transects

    Funded Work
  35. SCOPE Synthesis: Microbial control of nitrogen and iron cycling in the North Pacific Ocean

    Funded Work
  36. SCOPE Synthesis: Protistan Community Ecology in the NPSG

    Funded Work
  37. SCOPE Synthesis: Evaluating the role of cyanophages in shaping the ecology and biogeochemistry of the North Pacific Ocean

    Funded Work
  38. Eco-evolutionary virus-microbe dynamics on a continuum from lysis to latency

    Funded Work
  39. Mechanisms involved in nitroplast evolution

    Funded Work
  40. Boosting myelination as a therapeutic strategy in autism

    Funded Work
    Myelin, the lipid bilayer wrapping axons, contributes to increasing the conduction velocity of axons and to providing axonal metabolic support.
  41. SCOPE Synthesis: Phytoplankton interaction networks along Gradients transects

    Funded Work
  42. Cramped

    Funded Work
    Ten-episode limited series podcast hosted by Kate Downey, with episodes releasing weekly starting in February 2025.
  43. Math Circles of Chicago

    Funded Work
    Math organization creating meaningful and fun experiences that enable every student and educator to develop their mathematical power and build a sense of belonging in order to choose …
  44. Microbial Nitrogen Cycling: Novel organisms and enigmatic processes

    Funded Work
  45. SCOPE Synthesis: NPSG ecosystem dynamics project

    Funded Work
  46. SCOPE Synthesis: Assessing joint impacts of viruses and nutrients on marine microbial population and macromolecular dynamics

    Funded Work
  47. SCOPE Synthesis: BEACH laboratory NPSG ecosystem dynamics project

    Funded Work
  48. SCOPE Synthesis: Constraining diversity and productivity in the North Pacific

    Funded Work
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