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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Quantum Mechanics and Space-Time in the 21st Century

    January 11, 2012
    … Large Hadron Collider at CERN in Switzerland. University of California, Berkeley, Ph.D. 1997; SLAC National Accelerator Laboratory, Postdoctoral Fellow 1997–99; University of California, Berkeley, Assistant …
  2. Science Lives: Physicist Chen-Ning Yang (1922–2025)

    December 20, 2011
    A video interview, conducted on Feb. 22, 2011, with the Nobel Prize winning physicist Chen-Ning Yang. A video interview, conducted on Feb. 22, 2011, with the Nobel …
  3. Celebrating a milestone in autism research

    December 14, 2011
    More than 100 investigators and clinicians who worked together on the Simons Simplex Collection gathered in New York City to celebrate their landmark achievement in autism research.
  4. Stony Brook University 2011 Gift

    December 14, 2011
    The Simons Foundation is pleased to announce a challenge grant of $50M to the State University of New York at Stony Brook, in support of its Reimagining Stony …
  5. Science Lives: Mathematician Friedrich Hirzebruch (1927–2012)

    December 2, 2011
    … 18 August, 1952, after a nine-day crossing, Hirzebruch stepped off the Ryndam of the Holland America Line in Hoboken, New Jersey, where he was met by …
  6. Controlling Quantum Coherence: Toward New Paradigms of Computation

    November 30, 2011
    This talk describes experimental progress toward controlling quantum mechanical coherence and entanglement in a solid-state environment. After describing what coherence and entanglement are, I will explain why …
  7. Beautiful Thoughts from Ugly Neurons

    October 26, 2011
    … transformations of sensory encoding in olfaction, and the dynamics of internally generated activity and signal propagation in large neural networks. Most neural activity is generated internally but …
  8. Approximately Hard: The Unique Games Conjecture

    October 6, 2011
    A new conjecture has electrified computer scientists
  9. Workshop report: Biomarkers for autism research

    October 4, 2011
    Researchers can use biomarkers to diagnose individuals with autism and to hone in on the underlying causes of the disorder. In July, SFARI held an informal meeting of …
  10. 17 Gauss Way

    September 30, 2011
    Attracting mathematicians from around the world, the Mathematical Sciences Research Institute (MSRI) is perched atop the Berkeley hills with commanding views of San Francisco Bay and the Pacific …
  11. The Regulation of Fidelity in the Transmission of Genetic Information from Parent to Offspring

    September 28, 2011
    … of molecular biology and the physical sciences: on genetics and genomics, polymorphisms and molecular aspects of evolution, signal transduction pathways and networks, stress responses, and pharmacogenomics in …
  12. The Simons Simplex Collection’s inaugural paper published in Neuron

    August 22, 2011
    SFARI scientific director Gerald Fischbach and principal investigator Catherine Lord of the University of Michigan published The Simons Simplex Collection: A Resource for Identification of Autism Genetic Risk …
  13. SFARI announces new phase for Simons Simplex Collection

    August 19, 2011
    In a milestone for the autism research community, SFARI has finished recruiting families to participate in the Simons Simplex Collection (SSC). The foundation has now shifted from recruitment …
  14. Workshop report: Oxytocin and autism

    May 19, 2011
    Preliminary studies suggest that the so-called ‘love hormone’ oxytocin could improve some of the social deficits characteristic of people with autism. On 11 April, SFARI hosted a …
  15. The Global Math Commons

    May 18, 2011
    On the MathOverflow Web site, mathematicians from all over the world answer each other’s questions
  16. Merging Mind and Machine: Creating technology to reconnect the brain to action

    May 11, 2011
    … http://research.brown.edu/myresearch/John_Donoghue
  17. Workshop report: Attention deficits in autism

    May 3, 2011
    Children with autism often have behaviors that suggest problems with attention. It is unclear whether this attention deficit causes the other symptoms of autism or is a consequence …
  18. John W. Milnor

    April 28, 2011
    Aug. 30-Sept. 2, 1965 Soon after winning the Fields Medal in 1962, a young John Milnor gave these now-famous lectures and wrote his timeless Topology from …
  19. SFARI announces Explorer Awards program

    April 14, 2011
    SFARI is pleased to announce the SFARI Explorer Awards program: an initiative designed to provide timely support to innovative, high-risk experiments relevant to our mission.
  20. Computational Perspectives on Social Phenomena at Global Scales

    April 13, 2011
    … Research Council and the Scientific Advisory Board of the newly formed Simons Institute for the Theory of Computing at UC Berkeley. He is the author of the …
  21. Difficult decisions: An inside look at SFARI’s grant-making

    April 11, 2011
    In November, the Simons Foundation Autism Research Initiative (SFARI) launched a request for applications, calling for letters of intent from individuals who will conduct bold, imaginative and rigorous …
  22. Workshop report: Assays for mouse models of autism

    March 23, 2011
    Researchers need reliable methods to interpret autism candidate genes, including rodent models to assess the impact of genes on behavior. On 4 February, SFARI hosted a workshop to …
  23. The Missing Circuits: Studying Entire Brains

    March 23, 2011
    … have to be studied at the molecular/cellular level, neural circuit level, behavioral as well as social levels, and in multiple species. Given this complexity, there remain …
  24. The Geometry of Eero Saarinen’s Gateway Arch

    February 25, 2011
    Robert Osserman of MSRI discusses Saarinen’s soaring masterpiece
  25. When and How Can We Compute Approximately Optimal Solutions to Intractable Computational Problems?

    February 9, 2011
    … Probabilistically Checkable Proofs (PCPs), computing approximate solutions to NP-hard problems, geometric embedding of metric spaces, unique games conjecture, complexity of financial derivatives, provable bounds for Machine …
  26. A cautionary tale, and a case for evaluating autism genes

    February 1, 2011
    A study on a SHANK3 mutation highlights the danger in using research tools to inform decision-making in the doctor’s office. This sort of concern is one …
  27. Kindling the Mathematical Muse

    January 24, 2011
    North America’s only math museum prepares for 2012 opening
  28. Finding Nirvana in Numbers

    December 21, 2010
    … distanced me when I read about the history of mathematics. So, for example, I read a biography of the self-taught Indian mathematician Ramanujan and his famous …
  29. Unbiased Reconstruction of Mammalian Regulatory Networks

    December 15, 2010
    … professor in the department of biology at MIT and an Early Career Scientist at Howard Hughes Medical Institute. In 2008, she received the Overton Prize from the …
  30. Fluctuations, Information and Survival: Some Lessons from Bacteria

    November 17, 2010
    … theoretically. Dr. Leibler and his collaborators are developing new experimental techniques that will facilitate quantitative analysis of long-time population dynamics in microbial populations. In parallel, they …
  31. Normalization as a Canonical Neural Computation

    October 13, 2010
    … candidate for such a canonical neural computation is normalization, whereby the responses of a neuron is divided by a common factor, which typically includes the summed activity …
  32. UBE3A: What the HECT goes on in the brain?

    September 29, 2010
    Several studies have shown that a micro-duplication within 15q11-13 — a region on chromosome 15 — on the maternal chromosome is associated with autism. The duplicated region contains …
  33. Playing with Matches

    September 24, 2010
    … participants—might be behind the Roth-Peranson algorithm's success, since large markets tend to work better than small ones in many respects. To test this theory …
  34. Playing With Matches

    September 24, 2010
    Mathematics is helping medical students and hospitals solve the two-body problem
  35. Strategic Behavior and the Science of Social Networks

    September 22, 2010
    … He is an active member of Penn’s machine learning community PRiML, and am an affiliated faculty member of Penn’s Applied Math and Computational Science graduate …
  36. Workshop report: Neural circuits

    June 22, 2010
    Much of the recent advances in autism have been on the genetic and behavioral levels of dysfunction present in the disorder. Comparatively little is known about altered function …
  37. Why Sex?

    May 18, 2010
    Computer science proposes a new solution to one of evolutionary theory’s oldest problems.
  38. The Power and Weakness of Randomness (When You are Short on Time)

    May 12, 2010
    … respectively its power and weakness for making algorithms faster. I will address the role of randomness in other computational settings, such as space bounded computation and probabilistic …
  39. Workshop report: Fever and autism

    April 1, 2010
    On 5 February 2010, the Simons Foundation gathered a panel of experts to discuss what initially appears to be a surprising and unrelated pair of subjects: autism and …
  40. SFARI Gene launches animal model module

    March 25, 2010
    Sharmila Banerjee-Basu, founder and president of Mindspec Inc., and Alan Packer, associate director for research at SFARI, have published an article describing a new SFARI Gene module …
  41. Workshop Report: Sequencing

    January 22, 2010
    As the number of available DNA samples continues to increase and the cost of sequencing continues to drop, one can’t help but want to capture all of …
  42. Director’s column: Fever’s promising puzzle

    January 11, 2010
    Fever has benefits beyond its role in fighting infection. According to a prospective study published in 2007 and to many anecdotal reports, fever can improve cognitive function and …
  43. Director’s column: The gene-cognition gap

    October 8, 2009
    Autism research has attracted a remarkable diversity of scholars. Many of them have developed an understanding of concepts in fields that are not their own, but it is …
  44. Science Lives: Mathematician Isadore Singer (1924–2021)

    August 25, 2009
    … function defined over the entire manifold. It is very unusual for an integral that depends on a continuously varying parameter to take only integer values (as opposed …
  45. Mathematicians Solve 45-Year-Old Kervaire Invariant Puzzle

    July 20, 2009
    … many false proofs over the years, you start being suspicious, but this is completely different,” he added. “Their new method is very powerful. It’s clear that …
  46. Science Lives: Mathematician Michael Atiyah (1929–2019)

    July 15, 2009
    … perspectives, strengthening the bridge between analysis and topology with each one. The index theorem had turned into a field, index theory. Even in all the excitement, no …
  47. SFARI Gene launches

    February 24, 2009
    The SFARI team is pleased to announce the launch of SFARI Gene, a new online tool for autism researchers.
  48. Workshop report: The cognitive phenotype in autism

    October 1, 2008
    Autism is a developmental disorder characterized by impaired social interaction and communication, and restricted and repetitive behavior. Because there are no biological markers for the disorder, it is …
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