Cryo-Electron Microscopy

Revealing the innermost secrets of microscopic life.

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Cryo-EM produces 3D models of molecular structures at atomic resolution.

People

Structural cell biology is undergoing a computational revolution, and our scientists are leading the way.

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Rediet Abebe

Assistant Professor of Computer Science, University of California, Berkeley

Rhiannon Adam headshot

Rhiannon Adam

Photographic Artist

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Alexandre Adam

Flatiron Research Fellow, Centers for Computational Astrophysics and Computational Mathematics

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Ryan Adams

Investigator, Simons Collaboration on the Global Brain

Research Teams

Diagram showing cryo-EM: (a) electrons passing through a frozen sample, (b) resulting image with particles, (c) 3D structure reconstructed from multiple 2D images around the sample.

Heterogeneity in Cryo-EM

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CCBx

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Structural and Molecular Biophysics

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Image and Signal Processing

Research Spotlight

In this Presidential Lecture, Ellen Zhong describes the algorithmic challenges at the frontier of structure determination via cryo-EM.

Publications

Topological Phase Transitions Induced by Disorder in Magnetically Doped (Bi, Sb)\(_2\)Te\(_3\) Thin Films

October 13, 2026

Takuya Okugawa, Peizhe Tang, Rubio, Angel, and Dante M. Kennes

Single-particle spectral function formulated and calculated by variational Monte Carlo method with application to \(d\)-wave superconducting state

October 13, 2026

Charlebois, Maxime and Masatoshi Imada

Ultrasound evidence for a two-component superconducting order parameter in Sr\(_2\)RuO\(_4\)

October 13, 2026

S. Benhabib, C. Lupien, I. Paul, L. Berges, M. Dion, M. Nardone, et al.

Plaquette versus ordinary \(d\)-wave pairing in the \(t’\)-Hubbard model on a width 4 cylinder

October 13, 2026

C. Chung, Mingpu Qin, Zhang, Shiwei, Ulrich Schollwöck, and S. White

Feature

Twenty identical blue molecular structures are arranged in a 4 by 5 grid on a white background, each structure viewed from a slightly different angle.

Beyond the Cryo-EM Resolution Revolution

Scientists at the Simons Electron Microscopy Center use cryo-EM and related technologies to advance disciplines such as structural biology, biochemistry and medical science. Continue

News & Features

SFARI spotlight image.

Simons Foundation Announces 2026–2027 Class of SURFiN Fellows

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How Math Helped Argentine Sparrows Relearn Lost Songs

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Applications Open for 2027 Fellows-to-Faculty Award Program

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Applications Open for Simons Postdoctoral Fellowships in Plant Biology

Software & Data

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aLENS

Software
Simulates microtubule assemblies with motor proteins using Monte Carlo dynamics, constrained collision handling, and massive parallelization.

Astra

Software
Analysis framework for the Sloan Digital Sky Survey (SDSS-V) Milky Way Mapper.
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Astrometry.net

Software
Maps any astronomical image to sky coordinates (WCS) with no false positives, even without metadata, enabling real-time use across archives.
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BridgeStan

Software
BridgeStan gives in-memory access to Stan models via multiple languages, exposing log densities, gradients, Hessians, transforms, and predictions.

Community

Electron Microscopy Interest Group

Hosted by the Center for Computational Biology, this informal meeting series fosters new ideas and collaborations.

Learn More
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Talks & Lectures

GIZMO code dev meeting

October 12–14, 2026

Taking Pictures and Making Movies of Supermassive Black Holes

Lecture

October 14, 2026

6–7 p.m. ET

Speaker

Shep Doeleman

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2026 MPS Annual Meeting

Conference

October 15–16, 2026

AstroFest 2026

October 15, 2026

1–5 p.m. ET

Center for Computational Biology

CCB researchers are pioneering an approach that integrates theory, computation and experimentation—pushing the boundaries of biological inquiry.

Learn more
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