Exploring Cancer Drivers and Dependencies

The human body contains gene networks that naturally inhibit tumor development. This defensive arsenal includes repairing damaged DNA, suppressing inflammation and triggering the self-destruction of cells.

In this lecture, Scott W. Lowe will discuss his lab’s work exploring how the genetic alterations in cancer cells contribute to tumorigenesis, alter treatment response and create vulnerabilities that may be targeted therapeutically. He will outline how his team combines genetic, genomic and animal model approaches to comprehensively study cancer biology. He will also discuss tumor-suppressor gene networks and strategies to restore their function in advanced cancers.