The Machinery of Life Functions Inside a Very Crowded Cell

A living cell is an astonishingly complex environment. It is tightly packed with millions of molecular machines that do the work of the cell and provide structure, function and regulation. Over the last five years, electron microscopy (EM) has undergone a revolution. Advancements have catapulted EM to the forefront method for determining the detailed structures of these machines and how they interact inside the densely packed interior of cells. In this lecture, Bridget Carragher will explain the methods used, outline some of the current challenges and discuss opportunities for new advances.

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