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A woman with gray hair, blue eyes, and gold earrings smiles at the camera. She is wearing a light-colored shirt, and the background appears to be a blurred laboratory setting.

Jennifer Darnell, Ph.D.

Retired Associate Research Professor

Honorary Professor

Affiliations
  • The Rockefeller University
  • The University of Edinburgh
  • 2019

Jennifer Darnell is a retired associate research professor at the Rockefeller University and an honorary professor at the University of Edinburgh. During the course of her scientific career, Darnell focused on understanding the molecular mechanisms involved in fragile X syndrome, the most common monogenic cause of intellectual disability and autism.

Darnell is a current board member for the Simons Initiative for the Developing Brain at The University of Edinburgh. She also serves on the board of trustees for the Rocky Mountain Biological Laboratory (RMBL), a research facility that provides logistical support for scientists and students, including access to living quarters, research laboratories and protected research sites to accelerate discoveries about the local ecosystems that are critical to replenishing the world’s air, water and food supply.

Publications

FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory.

Elife, December 19, 2019

Sawicka K., Hale C.R., Park C.Y., Fak J.J., Gresack J.E., Van Driesche S.J., et al.

FMRP binding to a ranked subset of long genes is revealed by coupled CLIP and TRAP in specific neuronal cell types.

bioRxiv, September 10, 2019

Van Driesche S.J., Sawicka K., C. Zhang, Hung S.K.Y., Park C.Y., Fak J.J., et al.

Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis.

Nat. Protoc., January 31, 2014

Moore M.J., C. Zhang, Gantman E.C., Mele A., J. Darnell, and R. Darnell

De novo gene disruptions in children on the autistic spectrum.

Neuron, April 25, 2012

I. Iossifov, Ronemus M., Levy D., Wang Z., Hakker I., Rosenbaum J., et al.

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